亚临床甲状腺功能减退症和抑郁的相关性研究进展  

Research progress on the relationship between subclinical hypothyroidism and depression

作　　者：张涛涛 苏文秀 田利民[1,2,3] ZHANG Taotao;SU Wenxiu;TIAN Limin(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu,China;Department of Endocrinology,Gansu Provincial Hospital,Lanzhou 730000,Gansu,China;Gansu Clinical Research Center For Metabolic Diseases,Lanzhou 730000,Gansu,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院内分泌科,甘肃兰州730000 [3]甘肃省代谢性疾病临床医学研究中心,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2023年第8期954-960,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(82060152)。

摘　　要：亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)是甲状腺功能的轻度受损。现有的多项研究提示SCH与抑郁的风险增加有关,但也有研究发现SCH与抑郁之间并没有相关性。因此,SCH与抑郁之间是否存在关联及二者的相互作用机制仍有争议。近年来,越来越多的证据表明,SCH患者常规使用左旋甲状腺素治疗的疗效依然不明确,并且甲状腺疾病的治疗对各种临床精神结果的影响尚无定论。本文就SCH与抑郁风险的相关性及其是否需要药物干预治疗等研究现状进行综述。Subclinical hypothyroidism(SCH)is a mild impairment of thyroid function.Several existing studies suggest that SCH is associated with an increased risk of depression,but some studies have also found no correlation between SCH and depression.Therefore,whether there is an association between SCH and depression and the mechanism of interaction between the two remains controversial.Growing evidence suggested that SCH patients should not be routinely treated with levothyroxine,and the effect of the treatment of thyroid disease on various clinical psychiatric outcomes is also controversial.This article reviews the current research on the correlation between SCH and depression risk and whether drug intervention is needed.

关 键 词：亚临床甲状腺功能减退症 抑郁 左旋甲状腺素 相关性 

分 类 号：R581.2[医药卫生—内分泌] R749.4[医药卫生—内科学]