新的脂代谢调控基因——货运受体Surf4  

A Novel Lipid Metabolic Regulatory Protein:Cargo Receptor Surf4

作　　者：邢思捷 陶鸽如 秦树存 XING Si-Jie;TAO Ge-Ru;QIN Shu-Cun(Institute of Atherosclerosis,Second Affiliated Hospital of Shandong First Medical University,Tai’an 271000,Shandong,China)

机构地区：[1]山东第一医科大学动脉粥样硬化研究所和第二附属医院,山东泰安271000

出　　处：《中国生物化学与分子生物学报》2023年第5期633-637,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金海外及港澳台合作延续项目(No.91929002);学术提升计划潜力项目(No.2019QL010)资助。

摘　　要：Surf4属于Surfeit基因簇成员,在内质网膜中广泛表达和定位,作为货运受体参与多种蛋白质在内质网与高尔基体之间转运。新近发现,Surf4参加载脂蛋白B(Apo B)转运,进而影响极低密度脂蛋白(VLDL)前体的转运,在极低密度脂蛋白分泌中发挥调控作用,敲除肝Surf4能大幅度降低血浆总胆固醇和甘油三酯水平,不会造成肝的脂质堆积和病理改变。这些研究结果表明,Surf4可能是治疗心血管疾病的潜在药物靶标,在心血管疾病的发生发展及其诊疗中具有潜在的临床应用价值。本文就Surf4的主要生理功能,尤其是作为货运受体参与载脂蛋白B在内质网与高尔基体之间转运的货运功能,以及其参与调控脂代谢并与脂代谢相关疾病关系的研究进展进行系统阐述,以期促进对Surf4的认知,并为其深入研究和转化应用提供新思路,为降脂治疗提供新方法,造福于更多高脂血症患者。Surf4 is a member of the Surfeit gene cluster.It is widely expressed and localized in endoplasmic reticulum.As a cargo receptor,Surf4 participates in the transport of proteins between the endoplasmic reticulum and Golgi apparatus.It is newly discovered that Surf4 participates in the transport of apolipoprotein B,thus affecting the transport of very low density lipoprotein precursors.It plays a regulatory role in VLDL secretion.Knockout of liver Surf4 can significantly reduce plasma total cholesterol and triglyceride levels without inducing liver lipid accumulation and pathological changes.These results suggest that Surf4 may be a potential drug target and has potential value in the diagnosis and treatment of cardiovascular diseases.In this paper,the main physiological functions of Surf4,especially the transport function of apolipoprotein B transport between endoplasmic reticulum and Golgi apparatus as a transport receptor,as well as the research progress of its involvement in the regulation of lipid metabolism and related diseases,are systematically expounded.This paper can also improve in-depth research of Surf4 and its potential application as a new method of lipid-lowering therapy for hyperlipidemia patients.

关 键 词：Surf4 极低密度脂蛋白 脂代谢 载脂蛋白B 

分 类 号：R34[医药卫生—基础医学]