Exploring the mechanisms of lipid regulation in metabolic syndrome: Recent developments  

作　　者：Gui-Jie Wang Qian Shen Chuan-Long Zhang 

机构地区：[1]Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China [2]Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China

出　　处：《Medical Theory and Hypothesis》2023年第2期15-18,共4页医学理论与假说

摘　　要：Metabolic syndrome(MetS)is an individual accumulation of multiple abnormal metabolic indicators,with insulin resistance and central obesity at its core.Adipose tissue is the core component of MetS,and adipokines secreted by various adipocytes play a crucial role in its regulatory mechanism.In this paper,we searched the literature from 2020 to 2022 on Pubmed and Knowledgeweb using the keywords of“metabolic syndrome,”“adipose tissue”and“adipokines”.We mainly explored the mechanisms of leptin,lipocalin,resistin,brown adipose tissue and beige adipose tissue secreted by white adipose tissue in regulating insulin resistance,inhibiting inflammatory response and neurohormonal regulation of lipid and glucose metabolism.In this paper,under various studies on lipids for MetS,the metabolic mechanisms of various adipose tissues,adipocytes,and adipokines were investigated systematically and retrospectively.It was found that the regulation of adipokines and,thus,treatment of MetS by drugs is less and needs further exploration.

关 键 词：metabolic syndrome adipose tissue ADIPOKINES 

分 类 号：R58[医药卫生—内分泌]