Ⅰ型干扰素相关肾病  

TypeⅠinterferon-related kidney disorders

作　　者：康梅子 刘亚伟 戴兵 KANG Meizi;LIU Yawei;DAI Bing(Department of Nephrology,Kidney Disease Institute of PLA,The Second Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200003,China;Department of Nephrology,The Second Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu,China;Department of Internal Medicine,The Second Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200003,China)

机构地区：[1]海军军医大学(第二军医大学)第二附属医院肾内科,解放军肾脏病研究所,上海200003 [2]南通大学第二附属医院肾内科,南通226001 [3]海军军医大学(第二军医大学)第二附属医院内科教研室,上海200003

出　　处：《海军军医大学学报》2023年第8期958-964,共7页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81970640)。

摘　　要：当机体发生病毒感染、自身免疫异常和1型干扰素病等疾病时常常会出现增强的Ⅰ型干扰素(IFN-Ⅰ)信号转导通路活化,所有这些与IFN-Ⅰ活化相关的疾病均可导致肾脏损伤并有着相似的组织病理学特征。其机制既可以通过IFN-Ⅰ直接损伤肾脏足细胞、系膜细胞、内皮细胞和壁层上皮细胞,也可以通过IFN-Ⅰ活化诱发免疫反应介导肾小球损伤,这一类肾脏疾病被命名为IFN-Ⅰ相关肾病。本文对IFN-Ⅰ相关肾病的发病机制、病因分类、组织病理学特征、诊断及治疗作一综述。Enhanced typeⅠinterferon(IFN-Ⅰ)signaling pathway is observed in the setting of viral infections,autoimmune abnormality,type 1 interferonopathies,etc.All these IFN-Ⅰ-related disorders can cause renal dysfunction and share common histopathological features.The underlying mechanism lies in that IFN-Ⅰcan mediate kidney injury either by directly damaging several renal cell types(including podocytes,mesangial,endothelial and parietal epithelial cells)or promoting immune-mediated glomerular injury.This emerging spectrum of kidney diseases is defined as IFN-Ⅰ-related kidney disorders.This paper reviews the pathogenesis,etiological classification,histopathological characteristics,and diagnosis and treatment of the diseases.

关 键 词：塌陷性肾小球病变 Ⅰ型干扰素 系统性红斑狼疮 病毒感染 血栓性微血管病 

分 类 号：R692[医药卫生—泌尿科学]