N^(6)-甲基腺苷修饰与氧化应激的相互调控作用在疾病发生中的研究进展  

Research progress on the interaction between N^(6)-methyladenosine modification and oxidative stress in disease pathogenesiss

作　　者：王楠 何作顺 谷仕艳 WANG Nan;HE Zuo-shun;GU Shi-yan(School of Public Health,Dali University,Dali,Yunnan 671000,China)

机构地区：[1]大理大学公共卫生学院,云南大理671000

出　　处：《现代预防医学》2023年第15期2859-2863,共5页Modern Preventive Medicine

基　　金：国家自然科学基金(82060585,82260631);云南省科技厅青年项目(202001AU070015,202001BA070001-057)。

摘　　要：目的 对m^(6)A修饰与氧化应激的相互调控作用在疾病发生过程中的机制进行总结归纳。方法 检索Pub Med数据库、中国知网、万方数据库及维普数据库的相关文章,英文检索词为“m^(6)A modification,oxidative stress,disease”,中文检索词为“m^(6)A修饰、氧化应激、疾病”。排除重复性研究及部分相关性较低的文章,进行详细阅读并进行总结归纳。结果氧化应激可通过影响m^(6)A修饰的甲基转移酶、去甲基化酶和甲基结合蛋白,影响m^(6)A修饰的生物学效应;反过来,m^(6)A亦可通过调节Nrf2信号通路及ROS生成过程等参与氧化应激的发生发展。结论 本文对m^(6)A修饰与氧化应激相互调控的最新研究现状进行综述,能为氧化应激及m^(6)A修饰水平紊乱相关疾病的预防和治疗提供新的研究方向和思路。Objective To summarize the mechanism of the interaction between m^(6)A modification and oxidative stress in disease pathogenesis.Methods The related articles were searched in PubMed database,CNKI,Wan fang database,and VIP database with the English keywords of “m^(6)A modification”,“oxidative stress”,and “disease” and the corresponding Chinese keywords.Duplicated studies and some articles with low correlation were excluded,and the included studies were summarized.Results Oxidative stress can affect the biological effects of m^(6)A modification by affecting m^(6)A modified methyltransferase,demethylase,and methyl binding protein,and in turn,m^(6)A can also participate in the occurrence and development of oxidative stress by regulating Nrf2 signal pathway and ROS production process.Conclusion The latest research status of the mutual regulation of m^(6)A modification and oxidative stress is reviewed in this paper,providing new research directions and ideas for the prevention and treatment of diseases related to oxidative stress and disorder of m^(6)A modification level.

关 键 词：N^(6)-甲基腺苷修饰 氧化应激 甲基转移酶 去甲基化酶 甲基结合蛋白 

分 类 号：R181.2[医药卫生—流行病学]