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作 者:罗国平[1] 任婉婷 闫梦茹 孟会宁 LUO Guo-ping;REN Wan-ting;YAN Meng-ru;MENG Hui-ning(Pharmaceutical Institute,Xi′an Medical University,Xi′an 710021,China;Shandong Buchang Medicine Co.,Ltd.,Heze 274418,China)
机构地区:[1]西安医学院药学院,陕西西安710021 [2]山东步长医药销售有限公司,山东菏泽274418
出 处:《化学工程师》2023年第8期5-9,共5页Chemical Engineer
基 金:2021年陕西省教育厅青年创新团队项目(21JP113);陕西高校青年创新团队建设项目(陕教[2019]90号);西安医学院2020年国家级、省级和校级大学生创新创业训练计划项目(202011840016,S202011840016,121520016)。
摘 要:优化5-氨基乙酰丙酸盐酸盐(5-ALA)醇质体的制备工艺。选用大豆卵磷脂及胆固醇作为囊材,采用乙醇注入法制备5-ALA醇质体。以热敏性、包封率、变形性、粒度分布等为评价指标,分别采用单因素实验和正交实验优化工艺条件。最优制备条件为:m_((大豆卵磷脂))∶m_((胆固醇))=9∶1,m_((囊材))∶m_((药物))=23.3∶1,无水乙醇加入体积为10mL,PBS溶液的pH值为7.4,搅拌时间为30min,超声时间为4min。本实验优化得到的5-ALA光动力-热敏醇质体包封率较高,变形性较好,粒度分布均匀。To optimize the preparation conditions of 5-aminolevulinic acid hydrochloride(5-ALA)ethosomes.Soybean lecithin and cholesterol were used as capsule materials to prepare 5-ALA ethosomes by ethanol injection method.Taking thermal sensitivity,encapsulation ratio,deformability and particle size distribution as evaluation indexes,the process conditions were optimized by single factor test and orthogonal test.The optimum preparation conditions were as follows:m_((soybean lecithin))∶m_((cholesterol))=9∶1,m_((capsule material))∶m_((main drug))=23.3∶1,the volume of anhydrous ethanol added was 10mL,the pH of PBS solution was 7.4,the stirring time was 30min,and the ultrasonic time was 4min.The optimized 5-ALA photodynamic-thermosensitive ethosomes obtained in this experiment had high encapsulation efficiency,good deformability and uniform particle size distribution.
关 键 词:5-氨基乙酰丙酸盐酸盐 光动力作用 热敏醇质体 工艺优化 药剂学性质评价
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