Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes  

作　　者：Jiasong Cao Yixin Wang Shuqi Wang Yongmei Shen Wen Li Zhuo Weil Shanshan Li Qimei Lin Ying Chang 

机构地区：[1]Tianjin Key Laboratory of Human Development and Reproductive Regulation,Tianjin Central Hospital of Gynecology Obstetrics and Nankai University Affiliated Hospital of Obstetrics and Gynecology,Tianjin 300100,China [2]School of Clinical Medicine,Tianjin Medical University,Tianjin 300070,China

出　　处：《Maternal-Fetal Medicine》2023年第3期163-172,共10页母胎医学杂志（英文）

基　　金：supported by grants from the Natural Science Foundation of Tianjin,China(20JCYBJC01400 to Y.C.and 21JCYBJC00100 to J.S.C.);Open Project of Tianjin Key Laboratory of Human Development and Reproductive Regulation(2021XH05 to J.S.C.).

摘　　要：Steroid hormones,including progestagens,estrogens,androgens,corticosteroids,and their precursor cholesterol,perform essential functions in the successful establishment and maintenance of pregnancy and normal fetal development.As the core endocrine organ at the prenatal stage,the human placenta is involved in the biosynthesis,metabolism,and delivery of steroid hormones.Steroidogenic pathways are tightly regulated by placenta-intrinsic cytochrome P450 and hydroxysteroid dehydrogenase.However,the relationship between placental steroidogenic enzyme expression and adverse pregnancy outcomes is controversial.In this review,we summarize the possible upstream regulatory mechanisms of placental steroidogenic enzymes in physiologic and pathophysiologic states.We also describe the human placental barrier model and examine the potential of single-cell sequencing for evaluating the primary functions and cellular origin of steroidogenic enzymes.Finally,we examine the existing evidence for the association between placental steroidogenic enzyme dysregulation and adverse pregnancy outcomes.

关 键 词：PLACENTA Steroidogenic enzymes Maternal-fetal outcomes Cytochrome P450 Hydroxysteroid dehydrogenase 

分 类 号：R714.2[医药卫生—妇产科学]