宫腔粘连发病机制的研究进展  

Research progress on the pathogenesis of intrauterine adhesions

作　　者：刘昀华 朱宏涛(综述) 胡建国(审校)[1] LIU Yunhua;ZHU Hongtao;HU Jianguo(Department of Gynaecology and Obstetrics,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400072,China)

机构地区：[1]重庆医科大学附属第二医院妇产科,重庆400072

出　　处：《重庆医学》2023年第16期2535-2539,共5页Chongqing medicine

基　　金：国家自然科学基金青年科学基金项目(82103250)。

摘　　要：宫腔粘连(IUA)是多种因素导致子宫内膜损伤从而使子宫内膜纤维化的一种疾病,其容易导致女性闭经、不孕,严重危害女性的生殖功能和生理健康。子宫腔操作史是IUA的主要病因,目前研究主要集中于IUA的临床病因和组织病因,其分子学发病机制仍有待研究。现有治疗方式对中重度IUA疗效有限,复发率较高,因此探索发病机制,进而制订靶向治疗方案是一种可行方向。本文参考国内外文献,对IUA发病机制的最新研究进展做一定的阐述,以期为宫腔粘连的治疗提供新思路。Intrauterine adhesion(IUA)is a condition in which multiple factors contribute to damage and thus progression to fibrosis of the endometrium.This condition can result in amenorrhea and infertility in women,posing a significant threat to their reproductive function and overall physical well-being.The history of uterine cavity operations is the main cause of IUA.Current researches primarily focus on the clinical and tissue etiology of IUA,while the molecular pathogenesis of this condition still requires further study.Existing treatment methods have a limited curative effect on moderate to severe IUA,and the recurrence rate is high.Therefore,it is feasible to explore the pathogenesis and develop a targeted treatment plan.In this paper,the latest research progress on the pathogenesis of IUA was described,with reference to domestic and foreign literatures,in order to provide new ideas for the treatment of IUA.

关 键 词：子宫腔粘连 纤维化 转化生长因子-Β 自噬 信号通路 综述 

分 类 号：R711.74[医药卫生—妇产科学]