基于组织移植支撑再造乳头凸度研究进展  

Research progress in nipple projection reconstruction based on tissue graft support

作　　者：张小珊 邓呈亮 ZHANG Xiaoshan;DENG Chengliang(Department of Burns and Plastic Surgery,Collaborative Innovation Center for Tissue Damage Repair and Regenerative Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou,563003,P.R.China)

机构地区：[1]遵义医科大学附属医院烧伤整形外科、组织损伤修复与再生医学省部共建协同创新中心,贵州遵义563003

出　　处：《中国修复重建外科杂志》2023年第8期1031-1036,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：贵州省科技计划重点项目[黔科合基础-ZK(2021)重点011];省部共建协同创新中心项目[教科技厅函(2020)39号]。

摘　　要：目的对基于组织移植支撑再造乳头凸度的方法进行综述。方法回顾组织移植支撑再造乳头凸度相关研究文献,总结各种组织移植物的优缺点及乳头凸度改善结果。结果再造乳头凸度的丢失是患者满意度下降的常见原因,基于组织移植支撑再造乳头凸度是临床较常用方法,可以采用自体和同种异体组织。自体组织包括真皮组织、带真皮的脂肪组织、脂肪组织、耳软骨、肋软骨及对侧乳头组织,具有取材方便、无免疫排斥反应的优点,但可能导致供区损伤并延长手术时间。同种异体组织移植包括脱细胞真皮基质、冻干肋软骨及细胞外基质胶原蛋白、脱细胞乳头组织,不会对患者造成额外供区损伤,同时具有较高的可塑性,可根据受区情况进行设计利用,但成本较高限制了其应用发展。结论目前基于组织移植支撑再造乳头凸度技术没有金标准,自体、同种异体组织移植各有利弊,医师可根据患者情况选择合适的移植物。Objective To review the advances in methods for reconstructing nipple projection based on tissue graft support.Methods The literature related to nipple projection reconstruction based on tissue graft support was reviewed and summarized in terms of the advantages and disadvantages of various tissue grafts and the improved nipple projection results.Results Loss of nipple projection is a common cause of decreased patient’s satisfaction.Reconstructing nipple projection based on tissue graft support is a more common clinical method and can be done with autologous and allogeneic tissues.Autologous tissue grafts include dermis,adipose tissue with dermis,adipose tissue,ear cartilage,rib cartilage,and contralateral nipple tissue.Autologous tissue grafts are easy to obtain and have no immune rejection,but may lead to donor area damage and prolong the surgical time for tissue collection.Allogeneic tissue grafts include acellular dermal matrix,lyophilized rib cartilage,and extracellular matrix collagen,and decellularized nipple tissue.Allogeneic tissue grafts do not cause additional donor area damage,are highly malleable,and can be designed to be utilized according to the recipient area,but the high cost often limits the development of this technique.Conclusion There is no gold standard regarding tissue graft-assisted nipple projection reconstruction techniques,and there are advantages and disadvantages to both autologous and allogeneic tissue grafts.Surgeons should choose the appropriate graft based on the actual condition of the patient.

关 键 词：乳头再造 组织移植 乳头凸度 

分 类 号：R318.08[医药卫生—生物医学工程]