非编码RNA在骨H型血管生成中的调控作用  

Regulation of non-coding RNA in type H vessels angiogenesis of bone

作　　者：唐生平 廖世杰[1] 刘建宏 罗晓林 韦帧翟 丁晓飞[1] TANG Shengping;LIAO Shijie;LIU Jianhong;LUO Xiaolin;WEI Zhendi;DING Xiaofei(Department of Trauma Orthopedic and Hand Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning Guangxi,530021,P.R.China)

机构地区：[1]广西医科大学第一附属医院创伤骨科手外科,南宁530021

出　　处：《中国修复重建外科杂志》2023年第8期1042-1048,共7页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(82060396、82160809);广西医科大学青年科学基金项目(GXMUYSF202233)。

摘　　要：目的对非编码RNA(non-coding RNA,ncRNA)调控骨H型血管生成的相关研究进行综述。方法广泛查阅近年来国内外有关ncRNA调控骨H型血管生成的研究报道,并进行归纳总结。结果H型血管是一种特殊的骨血管亚型,具有偶联骨形成的能力。目前对于ncRNA在骨骼疾病中调控H型血管生成的研究主要集中于微小RNA、长链非编码RNA以及小干扰RNA,其可通过各自特有的作用方式影响缺氧诱导因子1α、PDGF-BB、神经轴突导向因子3等因子的表达,从而调控H型血管生成,参与骨骼疾病的发生发展。结论目前对于ncRNA调控H型血管生成的作用机制已有初步探索,随着研究深入,ncRNA有望作为诊断与治疗血管相关性骨骼疾病的新靶点。Objective To summarize the regulatory effect of non-coding RNA(ncRNA)on type H vessels angiogenesis of bone.Methods Recent domestic and foreign related literature about the regulation of ncRNA in type H vessels angiogenesis was widely reviewed and summarized.Results Type H vessels is a special subtype of bone vessels with the ability to couple bone formation.At present,the research on ncRNA regulating type H vessels angiogenesis in bone diseases mainly focuses on microRNA,long ncRNA,and small interfering RNA,which can affect the expressions of hypoxia inducible factor 1α,platelet derived growth factor BB,slit guidance ligand 3,and other factors through their own unique ways of action,thus regulating type H vessels angiogenesis and participating in the occurrence and development of bone diseases.Conclusion At present,the mechanism of ncRNA regulating bone type H vessels angiogenesis has been preliminarily explored.With the deepening of research,ncRNA is expected to be a new target for the diagnosis and treatment of vascular related bone diseases.

关 键 词：非编码RNA H型血管 血管生成 骨形成 调控 

分 类 号：R68[医药卫生—骨科学]