免疫信息学在表位疫苗研发中的应用与研究进展  

Application of Immunoinformatics in Epitope Vaccine Development

作　　者：冯宏盛 金行 高永宇 鲜钰涵 李海洋 杨思宇 贾爱明[4] 高凤山[1,2] FENG Hong-sheng;JIN Hang;GAO Yong-yu;XIAN Yu-han;LI Hai-yang;YANG Si-yu;JIA Ai-ming;GAO Feng-shan(College of Life and Health,Dalian University,Dalian 116622,China;The Dalian Gene and Protein Engineering for Drug Screening Key Laboratory,Dalian 116622,China;College of Veterinary Medicine,Jilin Agricultural University,Changchun 130118,China;The Second Hospital of Dalian Medical University,Dalian 116027,China)

机构地区：[1]大连大学生命健康学院,大连116622 [2]大连市基因和蛋白质工程药物筛选及研发重点实验室,大连116622 [3]吉林农业大学动物医学院,长春130118 [4]大连医科大学附属第二医院,大连116027

出　　处：《中国生物工程杂志》2023年第7期88-100,共13页China Biotechnology

基　　金：国家自然科学基金(32273022)资助项目。

摘　　要：对于表位疫苗的设计,通常是利用免疫信息学工具和相关技术方法对已获取或已知的核苷酸序列和氨基酸序列进行分析,以此确定和预筛选出可能的优势表位,之后通过人工合成或基因工程技术等制备具有优势表位的多肽疫苗。免疫信息学的快速发展使其被成功应用于疫苗学领域,成为开发基于表位多肽疫苗最有效的方法。从免疫信息学在表位疫苗设计中的一般流程及疫苗验证、表位疫苗研发涉及的免疫信息学工具以及免疫信息学在表位疫苗设计中的具体应用等方面进行综述,以期为合理设计和研发有效的表位疫苗提供参考。Presently,to design epitope vaccines,the research and development process is generally to use computer-aided immunoinformatics tools and related technical methods to analyze acquired or known nucleotide and amino acid sequences to determine and pre-screen out possible dominant epitopes,and then prepare polypeptide vaccines with dominant epitopes through synthetic or genetic engineering techniques.The rapid development of immunoinformatics has been successfully applied to the field of vaccinology,and the immunoinformatics method is the most effective method to develop vaccines based on epitope polypeptide.Immunoinformatics,the general process of immunoinformatics in epitope vaccine design and validation,the immunoinformatics tools involved in the design of epitope vaccines,and the specific application of immunoinformatics in the design of epitope vaccines are reviewed,which will provide reference for reasonable design and development of effective epitope vaccines.

关 键 词：免疫信息学 表位多肽 表位疫苗 

分 类 号：Q816[生物学—生物工程]