电化学生物传感器在乳腺癌肿瘤标志物检测中的研究进展  

Research Progress of Electrochemical Biosensor in the Detection of Tumor Markers in Breast Cancer

作　　者：姜嘉烨 吴娅芳 黄志强[1] 王英林 于影 谷志涛[2] 刘箐[1] JIANG Jia-ye;WU Ya-fang;HUANG Zhi-qiang;WANG Ying-lin;YU Ying;GU Zhi-tao;LIU Qing(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai Chest Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海交通大学附属胸科医院,上海200030

出　　处：《中国生物工程杂志》2023年第7期101-113,共13页China Biotechnology

基　　金：上海市医工交叉项目(1022308517)资助项目。

摘　　要：癌症的早期筛查和诊断是降低其发病率和死亡率的有效手段。乳腺癌是女性中最常见的恶性肿瘤,其发病率已超过肺癌。随着电化学技术的革新,加之生物传感器具有灵敏度高、检测快速、操作简单、成本低等优势,电化学生物传感器被广泛应用于乳腺癌标志物的检测。对常见的乳腺癌靶标进行分类概述,以电化学相关的免疫传感器和适配体传感器为分类,对国内外关于电化学生物传感器在乳腺癌肿瘤标志物的应用研究进行总结和讨论,并对其发展前景进行展望。Early screening and diagnosis of cancer is an effective means to reduce its incidence rate and mortality.Breast cancer is the most common malignant tumor among women,and has surpassed lung cancer to become the tumor with the highest incidence rate among women.With the innovation of electrochemical technology and the advantages of biosensors such as high sensitivity,rapid detection,simple operation and low cost,electrochemical biosensors are widely used in the detection of breast cancer markers.This review first summarizes the classification of common breast cancer biomarkers,and then summarizes and discusses the application of electrochemical biosensors in tumor markers of breast cancer at home and abroad,with electrochemical related immunosensors and aptamer sensors as the classification,and discusses their development prospects.

关 键 词：乳腺癌 早期诊断 肿瘤标志物 电化学生物传感器 

分 类 号：Q811[生物学—生物工程]