H3型犬流感病毒研究进展  

Advances on the study of H3 canine influenza

作　　者：肖妍 林大专[3] 毛泓月 鲁会军 韩继成[2,4] 金宁一[1,2] XIAO Yan;LIN Dazhuan;MAO Hongyue;LU Huijun;HAN Jicheng;JIN Ningyi(College of Veterinary Medicine,Northwest A&F University,Yangling 712100,China;Changchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences;Changchun Medical College;Academician Workstation,ChangchunUniversityof Chinese Medicin)

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]中国农业科学院长春兽医研究所 [3]长春医学高等专科学校 [4]长春中医药大学院士工作站

出　　处：《中国病原生物学杂志》2023年第9期1105-1109,共5页Journal of Pathogen Biology

基　　金：中国博士后科学基金(No.2022M713867);长春市科技发展计划项目(No.21ST03);吉林省中医药科技项目(No.2022129)。

摘　　要：犬流感是由犬流感病毒(canine influenza virus,CIV)引起的一种呼吸道传染病。1999年,H3N8马流感病毒(Equine influenza virus,EIV)首次在犬群中发现,从2004年起,H3N2禽流感病毒(Avian influenza virus,AIV)在亚洲和北美的家养犬群中持续流行,这是目前在世界范围内流行最为广泛的两种CIV亚型。全世界有多达9亿只家养犬,其中大多数作为家庭宠物存在,犬与人类的密切接触提高了CIV在人群与犬群之间相互传递的可能性。生活在犬舍、动物收容所这类高密度、高接触场所的犬以及城市中的流浪犬是导致CIV持续传播的主要原因。CIV的突变和跨物种传播,使不同来源不同亚型的流感病毒在犬体内发生重组,所以CIV的进化与传播极有可能对人类社会的公共卫生安全构成一定的威胁。本论文主要综述CIV来源、致病性以及防治方法,旨在为后续H3型犬流感的防控提供参考。Canine influenza is a respiratory infectious disease caused by canine influenza virus(CIV).In 1999,equine influenza virus(EIV)H3N8 was found in dogs for the first time.Since 2004,avian influenza virus(AIV)H3N2 has been continuously prevalent in domestic dogs in Asia and North America.H3N8 and H3N2 are the major CIV subtypes in the world.There are as many as 9oo million domestic dogs in the world,most of them are raising as family pets.Because of the intimate interaction between dogs and humans,the possibility of CIV transmission between people and dogs was improved.Dogs which have been living in kennels,animal shelters and other high-density and high contact places,as well as stray dogs in cities,are the main reasons for the continuous transmission of CIV.The mutation and cross-species transmission of CIV make influenza viruses from different sources and subtypes recombine in dogs,so the evolution and transmission of CIV is likely to pose a certain threat to the public health security of human society.This paper mainly reviews the source,pathogenesis and prevention methods of CIV,aiming to provide reference for the prevention and control of H3 canineinfluenza.

关 键 词：犬流感 流感病毒 流行病学 病毒重组 疫苗 综述 

分 类 号：R373.14[医药卫生—病原生物学]