肠道微生物介导的色氨酸代谢与肠粘膜屏障研究进展  

Research progress on intestinal microbe- mediated try ptophan metabolism and intestinal mucosal barrier

作　　者：巩家慧 孔令斌[2] 张帆[2] GONG Jiahui;KONG Lingbin;ZHANG Fan(Clinical Medical College of Jining Medical University,J ining,Shandong 272067,China;Jining Medical University)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]济宁医学院

出　　处：《中国病原生物学杂志》2023年第9期1110-1113,共4页Journal of Pathogen Biology

基　　金：山东省医药卫生科技发展计划项目(No.202003030503);济宁医学院科研创新团队(培育)项目—早期胃癌诊治团队(校级培育22)。

摘　　要：在肠道微生物的作用下,色氨酸可代谢为吲哚-3-丙酸、吲哚乳酸、吲哚等多种代谢产物,它们作为宿主-微生物交叉交流中的重要媒介,可通过维护肠粘膜屏障,从而起到维护肠道和宿主内稳态的重要作用。目前,色氨酸代谢产物与肠粘膜屏障的关系尚未明确。本文主要从微生物源的色氨酸代谢产物对肠黏膜屏障调控作用的近期研究成果进行概述,以期为外源性色氨酸代谢产物防治肠道疾病提供新思路。Under the action of intestinal microorganisms,tryptophan can be metabolized into indole-3-propionic acid,indole-lactic acid,indole and other metabolites.As an important medium in host-microbial cross communication,tryptophan can play an important role in maintaining intestinal and host homeostasis by maintaining intestinal mucosal barrier.At present,the relationship between tryptophan metabolites and intestinal mucosal barrier is not clear.In this paper,we summarize the recent research results on the protective effect of microbial mediated tryptophan metabolites on gut barrier in order to provide new ideas for the prevention and treatment of intestinal diseases by exogenous TRP metabolites.

关 键 词：色氨酸代谢产物 肠道微生物 肠粘膜屏障 综述 

分 类 号：R378[医药卫生—病原生物学]