中枢神经系统活动异常在耳鸣发生中的作用与机制  

The role and mechanism of abnormal central nervous system activity in the occurrence of tinnitus

作　　者：张红[1] 李欣[1] ZHANG Hong;LI Xin(Department of Otorhinopharyngology&Head and Neck Surgery,Beijing Tsinghua Changgung Hospital/School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]清华大学附属北京清华长庚医院/清华大学临床医学院耳鼻咽喉头颈外科,北京102218

出　　处：《山东大学耳鼻喉眼学报》2023年第4期24-29,37,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：耳鸣指患者在缺乏外部声源的情况下,耳内或颅内产生嗡嗡声、嘶鸣等异常声幻觉的现象。伴随着临床研究对耳鸣发病机制的不断深入,越来越多的研究分析显示,中枢神经系统活动在耳鸣患者发病机制中存在密切的关联。然而,影响中枢神经系统活动的因素复杂多样。因此,通过中枢神经系统的作用机制对耳鸣症状进行探究,对于缓解患者临床症状、减轻耳鸣对日常工作和生活造成的影响具有重要的研究意义。本研究结论显示,主观性耳鸣的发病机制与中枢神经系统存在密切关联;微量元素的异常以及边缘系统功能的异常同样可能对耳鸣的发生发展发挥推动作用,通过阻断上述影响机制的作用通路,可对耳鸣患者症状的缓解发挥一定的作用,从而为耳鸣患者的治疗提供新的思路。Tinnitus refers to the perception of noise without an external sound source,ear or intracranial buzzing,hoarseness,and other abnormal sound illusion phenomena.With the development of clinical research on the pathogenesis of tinnitus,additional studies and analyses show that central nervous system activity is closely related to the pathogenesis of tinnitus.However,the factors affecting central nervous system activity are complex and diverse.Therefore,it is critical to investigate tinnitus symptoms through the mechanism of the central nervous system to relieve the clinical symptoms and the effects of tinnitus on daily work and life.Thus,this study observed that the pathogenesis of subjective tinnitus is closely related to the central nervous system.Limbic system function may also contribute to the development of tinnitus by blocking the pathways of these mechanisms;it may also contribute to the relief of tinnitus symptoms,thus providing a new approach to treating tinnitus patients.

关 键 词：中枢神经系统活动 耳鸣发病机制 边缘系统 精神症状 微量元素 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]