细胞感应基质机械力学信号的过程与机制  

Research process and mechanisms of cellular sensing of matrix mechanical signals

作　　者：王鹏[1] 魏强[1] WANG Peng;WEI Qiang(College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China)

机构地区：[1]四川大学高分子科学与工程学院,高分子材料工程国家重点实验室,成都610065

出　　处：《生命的化学》2023年第7期947-958,共12页Chemistry of Life

基　　金：国家自然科学基金项目(T2222020)。

摘　　要：随着细胞力学的发展以及对细胞力学生物学的深入研究,细胞外基质中的机械信号对细胞的黏附、增殖、分化和凋亡等过程的重要作用也被逐步揭示出来。细胞通过细胞膜上的黏附蛋白与基质中的黏附配体之间的相互作用感知基质机械力学信号,进而调控细胞力学信号转导,并最终使细胞核力学信号发生改变,从而得以调节细胞的增殖迁移、组织的形成以及癌症发生等重要生命活动。本文详细介绍了细胞力学生物学的发展脉络,综述了细胞与微环境的相互作用并深入阐述了细胞力学信号转导的过程与机制。W:ith the advancement of cellular mechanics and in-depth investigations into the field of cellular mechanobiology,the crucial role of mechanical signals in the extracellular matrix(ECM)has gradually emerged in processes such as cell adhesion,proliferation,differentiation,and apoptosis.Cells perceive matrix mechanical signals through the interaction between adhesion proteins on the cell membrane and adhesive ligands within the matrix,subsequently regulating cellular mechanotransduction.This ultimately leads to changes in nuclear mechanics,thereby governing vital cellular activities including migration,tissue formation,and cancer development.In this paper,we provide a comprehensive overview of the development of cellular mechanics in biology,elucidate the interplay between cells and their microenvironment,and delve into the intricate processes and mechanisms of cellular mechanotransduction.

关 键 词：细胞 整合素 微环境 力学生物学 力学信号转导 细胞核力学 

分 类 号：R318.01[医药卫生—生物医学工程]