整合素的活性调控及其功能  

The influence of integrin activity regulation on its biological function

作　　者：郑韫哲 黄梦汶 陈剑峰 ZHENG Yunzhe;HUANG Mengwen;CHEN Jianfeng(State Key Laboratory of Cell Biology,CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China;Key Labory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China)

机构地区：[1]中国科学院分子细胞科学卓越创新中心,上海200031 [2]中国科学院上海生物化学与细胞生物学研究所,细胞生物学国家重点实验室,中国科学院大学,国科大杭州高等研究院生命与健康科学学院,中国科学院大学,浙江省系统健康科学重点实验室,杭州310024

出　　处：《生命的化学》2023年第7期967-974,共8页Chemistry of Life

基　　金：国家重点研发计划项目(2020YFA0509102);国家自然科学基金项目(32030024,31830112);上海市优秀学术带头人项目(19XD1404200)。

摘　　要：整合素是一类广泛表达于细胞表面的黏附分子,能够感知细胞内外刺激,通过双向跨膜信号调控细胞黏附与迁移、细胞生存、免疫监视、凝血、发育等多种生理过程。整合素在细胞膜表面通常以折叠的非活化构象存在,而在接受活化信号后,可以转变为伸展的活化构象。整合素活化状态的转变与其本身的内化及再循环过程以及细胞正常生理活动紧密相关;而整合素活性调节异常会导致多种疾病的发生。整合素动态活化是整合素活化蛋白和去活化蛋白共同作用的结果。本文将对整合素活性调控与细胞迁移以及相关疾病发生过程中其活性的转变进行概述,同时也对目前已知的为数不多的整合素去活化蛋白进行简要的介绍。Integrins are transmembrane adhesion molecules expressed ubiquitously on cell surface,which regulate various physiological processes including cell adhesion,migration,survival,immune surveillance,thrombosis,and development through signal transduction by sensing intracellular and extracellular stimulation.Integrins usually exist in an inactive conformation on the cell surface,but can be change to an extended active conformation regulated by inside-out and outside-in signaling.The transformation of integrin activation state is closely related to its internalization and recycling process as well as the normal physiological cell activity.Many diseases are associated with the deregulation of integrin activity.The normal function of integrin is the result of the balance between activation and inactivation.Here,we discuss the dynamic transformation of integrin activity during cell migration and disease development,and we also review the integrin-inactivating proteins.

关 键 词：整合素 活化 去活化 细胞迁移 

分 类 号：R346[医药卫生—基础医学]