正常听力儿童事件相关电位P1波及失匹配负波随年龄的变化规律  

The age changes of event related potential P1 and mismatch negativity in normal hearing children

作　　者：赵诗扬 蒋妍 吴文静 张秋敏 王媛[1] 费文轩 王硕[1] ZHAO Shiyang;JIANG Yan;WU Wenjing;ZHANG Qiumin;WANG Yuan;FEI Wenxuan;WANG Shuo(Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Liaocheng,Shandong,252004,China;Department of Child Healthcare,Liaocheng Dongchangfu District Maternal and Child Health Hospital,Liaocheng,Shandong,252004,China;Department of Ophthalmology and otorhinolaryngology,Liaocheng Dongchangfu District Maternal and Child Health Hospital,Liaocheng,Shandong,252004,China)

机构地区：[1]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,耳鼻咽喉头颈科学教育部重点实验室(首都医科大学),北京市耳鼻咽喉科研究所,山东聊城252004 [2]山东省聊城市东昌府区妇幼保健院儿童保健科,山东聊城252004 [3]山东省聊城市东昌府区妇幼保健院眼耳鼻喉科,山东聊城252004

出　　处：《中国耳鼻咽喉头颈外科》2023年第7期430-433,共4页Chinese Archives of Otolaryngology-Head and Neck Surgery

基　　金：国家自然科学基金资助项目(81870715、81200754);首都卫生发展科研专项(首发2022-1-2023)。

摘　　要：目的 探究正常听力儿童事件相关电位(event related potential,ERP)中P1波及失匹配负波(mismatch negativity,MMN)随年龄增长的变化规律以及听觉皮层的发育情况。方法 招募2~11岁儿童,在排除听力问题后,于隔声室内静坐进行听觉诱发电位测试。分析随年龄变化P1波以及MMN的振幅和潜伏期的发展趋势。结果 P1波以及MMN的潜伏期均与儿童年龄增长存在显著负相关,P1波的潜伏期在各年龄组间比较存在显著性差异,而MMN的潜伏期仅在2~3岁小龄组存在显著性延后。结论 伴随儿童年龄的增长,由言语声诱发的P1波和MMN的潜伏期存在逐渐缩短的趋势,听觉皮层的功能不断发育,因此在临床听觉康复中的效果应根据年龄进行评估。OBJECTIVE To study the development of P1 and mismatch negativity(MMN) of event related potential(ERP) which evoked by syllable sound with age increasing in normal hearing children and explore the maturity of auditory cortex.METHODS Children aged 2-11 years were recruited and divided into five groups according to age.After eliminating hearing problems,the subjects sat quietly in the sound-proof room for auditory evoked potential test.The development trend of P1 component and MMN with age were analyzed.RESULTS There was a significant negative correlation between the latency of P1 wave,MMN and the increase of children's age,besides there were significant differences between age groups in the latency of P1 wave.The delay of MMN latency was significant in the group of 2-3 years old.CONCLUSION Age growth in childhood has a significant impact on the latency of P1 and MMN.The functions of auditory cortex have development during the period of 2-11 years.Therefore,the effect of clinical auditory rehabilitation should be assessed according to age.

关 键 词：诱发电位 儿童 事件相关电位 失匹配负波 P1波潜伏期 

分 类 号：R764[医药卫生—耳鼻咽喉科]