尿毒清颗粒对腹膜透析患者残余肾功能及腹透液纤连蛋白和TGF-β1水平的作用  

Effect of Niaoduqing granules on residual renal function and levels of fibronectin and TGF-β1 in peritoneal dialysate of peritoneal dialysis patients

作　　者：罗阳燕 王少清 高芳[1] 沈艳 张万军 李莉 Luo Yangyan;Wang Shaoqing;Gao Fang;Shen Yan;Zhang Wanjun;Li Li(Department of Nephrology,First Affiliated Hospital of Chengdu Medical College,Chengdu 610500;Second Affiliated Hospital of Chengdu Medical College/416 Hospital of Nuclear Industry,Chengdu 610000;Chongzhou Second People′s Hospital,Chongzhou 611230;Guanghan Second People′s Hospital,Guanghan 618300;903 Hospital,Jiangyou 621700,Sichuan Province,China)

机构地区：[1]成都医学院第一附属医院肾病科,610500 [2]成都医学院第二附属医院、核工业四一六医院,610000 [3]崇州市第二人民医院,611230 [4]广汉市第二人民医院,618300 [5]江油市903医院,621700

出　　处：《中华肾病研究电子杂志》2023年第4期200-204,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：四川省医学科研青年创新课题(Q17024);成都医学院第一附属医院独立资助课题(CYFY15DL-07)。

摘　　要：目的探讨尿毒清颗粒对腹膜透析(PD)患者的残余肾功能以及纤连蛋白(FN)和TGF-β1水平的作用。方法选取四家医院因终末期肾脏病进行PD治疗的103例患者,随机分为试验组52例和对照组51例。对照组仅进行PD治疗;试验组则在PD治疗的基础上口服尿毒清颗粒治疗,持续12月。比较两组患者治疗前、后的残余肾功能(RRF)、尿量、残肾Kt/V、残肾肌酐清除率(Ccr)、纤维连接蛋白(FN)、TGF-β1的水平变化。结果治疗12个月后,对照组和试验组患者的RRF、残肾Kt/V、残肾Ccr水平均较治疗前降低(P<0.05),而试验组的上述指标水平则高于对照组(P<0.05)。此外,治疗后,试验组患者腹透液中的FN、TGF-β1水平降低,并且低于对照组的治疗后水平(均P<0.01)。结论尿毒清颗粒可以改善PD患者残余肾功能,降低腹透液的FN、TGF-β1水平,提示还可能具有抑制腹膜纤维化的作用。Objective To investigate the effect of Niaoduqing granules on residual renal function(RRF)and levels of fibronectin(FN)and TGF-β1 in peritoneal dialysate of peritoneal dialysis patients.Methods A total of 103 end-stage kidney disease patients who underwent PD treatment in the four hospitals were enrolled,and randomly divided into an experimental group of 52 cases and a control group of 51 cases.The control group received PD treatment,while the experimental group received oral Niaoduqing granules on the basis of PD treatment for 12 months.The two groups were compared in changes of RRF,urine volume,residual Kt/V,residual creatinine clearance rate(Ccr),FN,and TGF-β1 before and after the treatment.Results After 12 months of treatment,the levels of RRF,residual Kt/V,and residual Ccr were lower in both groups(P<0.05),but were higher in the experimental group than in the control group(P<0.05).In addition,after treatment,the levels of FN and TGF-β1 in the peritoneal dialysate of the experimental group decreased significantly,and were also lower than those of the control group(all P<0.01).Conclusion Niaoduqing granules improved the RRF of the PD patients,and reduced the expression of FN and TGF-β1 implicating that Niaoduqing granules might also have an inhibitory effect on peritoneal fibrosis.

关 键 词：尿毒清颗粒 腹膜透析 残余肾功能 腹膜纤维化 

分 类 号：R692.5[医药卫生—泌尿科学] R572.2[医药卫生—外科学]