Toll样受体在脓毒症性急性肾损伤中的作用  

Role of Toll-like receptor in sepsis-induced acute kidney injury

作　　者：苗软昕 乔晞[1] Miao Ruanxin;Qiao Xi(Department of Nephrology,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]山西医科大学第二医院肾内科,太原030001

出　　处：《中华肾病研究电子杂志》2023年第4期210-214,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：山西省回国留学人员科研资助项目(2020-186);山西省留学回国人员科技活动择优资助项目(2017-29)。

摘　　要：脓毒症导致的急性肾损伤(SIAKI)是危重症患者中最常见的急性肾损伤(AKI)类型,其发病机制复杂,而过度的炎症反应则起着关键作用。Toll样受体(TLRs)介导的信号通路能够介导促炎细胞因子的转录、肾内炎症反应,进而导致肾脏损伤。本文就TLRs的生物学特性及其在SIAKI中的作用做一综述,旨在为探索SIAKI的治疗干预靶点提供思路。Sepsis-induced acute kidney injury(SIAKI)is the most common type of acute kidney injury(AKI)in critically ill patients.Its pathogenesis is complex,in which excessive inflammation plays a key role.Toll-like receptors(TLRs)mediate signal pathways that can contribute to the transcription of pro-inflammatory cytokines,inflammation in the kidney,and lead to kidney injury.This article reviewed the biological characteristics of Toll-like receptors as well as their roles in SIAKI,aiming to provide ideas for exploring the therapeutic intervention targets of SIAKI.

关 键 词：TOLL样受体 脓毒症 急性肾损伤 炎症 

分 类 号：R692[医药卫生—泌尿科学] R459.7[医药卫生—外科学]