肠道菌群及其代谢产物在急性肾损伤中的作用研究进展  

Progress of research on the roles of gut microbiota and its metabolites in acute kidney injury

作　　者：李娜[1] 朱国贞[1] Li Na;Zhu Guozhen(Department of Nephrology,Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]山西医科大学第二医院肾内科,太原030001

出　　处：《中华肾病研究电子杂志》2023年第4期215-219,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：山西省自然科学研究面上项目(202103021224420)。

摘　　要：急性肾损伤(AKI)导致肠道菌群失调,而失调的肠道菌群会加重AKI进展,从而形成肠-肾恶性循环。肠道益生菌及其代谢产物可能通过阻断肠-肾恶性循环而具有抑制AKI进展作用,有可能会成为AKI的新疗法。本文就肠道菌群在AKI中作用的研究进展作一综述。Studies have found that AKI could lead to gut microbiota imbalance, while the imbalance of gut microbiota could aggravate the progression of AKI, forming a gut-kidney vicious cycle. Probiotics and their metabolites might inhibit the progression of AKI by blocking the gut-kidney vicious cycle, which may become a new therapy for AKI. This article reviewed the progress of research on the role of gut microbiota in AKI.

关 键 词：肠道菌群 急性肾损伤 益生菌 短链脂肪酸 D-丝氨酸 

分 类 号：R692[医药卫生—泌尿科学] R747.9[医药卫生—外科学]