肺周细胞及其作为特发性肺纤维化治疗靶点的潜力  

Pulmonary pericytes and their potential as therapeutic targets in idiopathic pulmonary fibrosis

作　　者：刘鹏程 余淑娇[1] 彭一琳 吴锐[1] LIU Pengcheng;YU Shujiao;PENG Yilin;WU Rui(Department of Immunology and Rheumatology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院风湿免疫科,南昌330006

出　　处：《生命的化学》2023年第6期847-854,共8页Chemistry of Life

基　　金：国家自然科学基金项目(82260898)。

摘　　要：肺接受来自肺循环和支气管循环的双重血液供应,是一个高度血管化的器官。而周细胞在血管形态和稳态中发挥着重要的调节作用,并与内皮细胞共同构成微血管。随着全世界学者孜孜不倦的探索,人们对肺周细胞的特性及诸多功能有了全新的认识。目前,已有大量研究表明,肺周细胞在特发性肺纤维化中发挥重要作用,并且可能成为一种未来潜在的治疗靶点。本文将就肺周细胞的特性、标志、功能以及未来新的治疗靶点进行概述。The lung is a highly vascularized organ and receives a dual blood supply from the pulmonary and bronchial circulations.Pericytes are combined with endothelial cells to form microvessels,which has an important regulatory effect in regulating vascular morphology and homeostasis.Through tireless exploration by scholars worldwide,a new understanding of the properties and functions of pulmonary pericytes has emerged.Numerous studies have revealed that pulmonary pericytes played a vital role in idiopathic pulmonary fibrosis and could serve as a potential therapeutic target in the future.This paper reviewed the research on the characteristics,markers,functions and new therapeutic targets of pulmonary pericytes.

关 键 词：肺周细胞 生物标志物 新治疗靶点 

分 类 号：R563[医药卫生—呼吸系统]