CD137^(+)T细胞效应功能研究进展  

Research progress of CD137^(+)T cells effector function

作　　者：姬雪娇 沈洪波 王菲菲[3] 郑碧英 JI Xuejiao;SHEN Hongbo;WANG Feifei;ZHENG Biying(Department of Clinical Immunology,Institute of Clinical Laboratory Medicine,Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,Guangdong Medical University,Dongguan 523808,China;Clinic and Research Center of Tuberculosis,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China;Key Laboratory of Medical Molecular Virology,MOE/NHC/CAMS,Shanghai Institute of Infectious Disease and Biosecurity,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)

机构地区：[1]广东医科大学检验医学研究所临床免疫学研究室,东莞523808 [2]同济大学附属上海市肺科医院结核病临床研究中心,上海200433 [3]复旦大学上海医学院基础医学院病原生物学系、教育部、卫健委、医科院医学分子病毒学重点实验室,上海200032

出　　处：《生命的化学》2023年第6期915-921,共7页Chemistry of Life

基　　金：上海市自然科学基金项目(20ZR1406200,20ZR1446900)。

摘　　要：CD137^(+)(又称4-1BB、TNFRSF9)T细胞亚群是一类抗原特异性活化的效应细胞。CD137^(+)T细胞产生细胞毒效应因子以及在抗原刺激后进行增殖的能力较强,使其在多种疾病中发挥免疫调节作用,其中CD137^(+)调节性T细胞分泌的分泌型CD137具有重要的免疫抑制作用。因此,全面了解CD137^(+)T细胞在疾病中的作用,对开发有效的疾病免疫防治策略至关重要。本文通过介绍CD137相关信号对T细胞尤其是CD8^(+)T细胞功能的调控机制、CD137^(+)T细胞的特征和效应功能、CD137^(+)T细胞在多种疾病进展中的免疫调控作用,为靶向CD137^(+)T细胞的免疫治疗提供参考。CD137^(+)(also named 4-1BB;tumor necrosis factor receptor superfamily 9,TNFRSF9)T cells are antigen-specific activated effector cells.CD137^(+)T cells have a strong ability to proliferate and produce cytotoxic effector factors after antigen stimulation,enabling them to play an immunomodulatory role in various diseases.Among these CD137^(+)T cells,the soluble CD137 protein secreted by CD137^(+)regulatory T cells has a potent anti-inflammatory effect.Therefore,a comprehensive understanding of the role of CD137^(+)T cells in disease is essential to develope effective disease immune prevention strategies.This review focuses on the regulatory mechanism of CD137-related signals on the function of T cells,especially CD8^(+)T cells,the characteristics and effector functions of CD137^(+)T cells,and the immunoregulatory role of CD137^(+)T cells in the progression of various diseases.This review aims to provide implications for the immunotherapy of CD137^(+)T cells in the future.

关 键 词：CD137^(+)T细胞 抗原特异性T细胞 免疫微环境 免疫治疗 

分 类 号：R392.12[医药卫生—免疫学]