基于免疫-炎症反应轴探究大株红景天辅助纳美芬治疗一氧化碳中毒迟发脑病的疗效及安全性  

Efficacy and safety of Rhodiola Rosea assisted nalmefene in the treatment of delayed encephalopathy caused by carbon monoxide poisoning based on immune-inflammatory response axis

作　　者：关菲[1] 么颖 王菲 赵桐[1] GUAN Fei;YAO Ying;WANG Fei;ZHAO Tong(Tangshan People’s Hospital,Tangshan 063000,China)

机构地区：[1]唐山市人民医院,河北唐山063000

出　　处：《中国实用神经疾病杂志》2023年第9期1091-1096,共6页Chinese Journal of Practical Nervous Diseases

基　　金：河北省医学科学研究课题计划(编号:20191581)。

摘　　要：目的基于免疫-炎症反应轴探究大株红景天辅助纳美芬治疗一氧化碳中毒迟发脑病(DEACMP)的疗效及安全性。方法选取2020-01—2023-01唐山市人民医院收治的114例DEACMP患者,随机分为3组各38例。对照A组予以纳美芬,对照B组予以大株红景天,观察组予以大株红景天辅助纳美芬。1个疗程10 d,共治疗4个疗程。比较3组临床疗效及治疗前及治疗1个疗程、4个疗程氧化应激反应[一氧化氮合酶(iNOS)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平、免疫-炎症反应轴[高迁移率族蛋白1(HMGB1)、白细胞介素(IL-17)]、蒙特利尔认知评估量表(MoCA)、简易智能精神状态检查量表(MMSE)、Barthel指数(BI)、Berg平衡量表(BBS)、健康检查简表(SF-36)。结果观察组临床总有效率高于对照A、B组(P<0.05);治疗1个疗程、4个疗程观察组iNOS、MDA、HMGB1、IL-17均低于对照A、B组,SOD高于对照A、B组(P<0.05);MMSE、MoCA、BI、BBS及SF-36评分均高于对照A、B组(P<0.05)。结论大株红景天辅助纳美芬治疗DEACMP患者效果显著,能减轻氧化应激反应,改善炎症-免疫动态平衡、平衡功能及认知功能,提高生活质量,且具有较高安全性。Objective To investigate the efficacy and safety of Rhodirosea Rosea assisted nalmefene in the treatment of delayed encephalopathy(DEACMP)caused by carbon monoxide poisoning based on immune-inflammatory response axis.Methods Totally 114 patients with DEACMP in Tangshan Pepole’s Hospital from January 2020 to January 2023 were randomly divided into 3 groups with 38 cases in each group.Control group A was given nalmefene,control group B was given large Rhodiola Rosea,observation group was given large Rhodiola Rosea adjuvant nalmefene.A course of treatment lasted for 10 days and a total of 4 courses.The clinical efficacy,oxidative stress response[nitric oxide synthase(iNOS),superoxide dismutase(SOD),malonaldehyde(MDA)]levels,immune-inflammatory response axis[high mobility group protein 1(HMGB1),interleukin(IL-17)],Montreal cognitive assessment(MoCA)scale,mini mental state examination(MMSE)scale,Barthel index(BI),Berg balance scale(BBS),the Mos item shortform health survey(SF-36)were compared among the 3 groups before treatment,1 course of treatment,4 courses of treatment.Results The total effective rate of observation group was higher than that of control groups A and B(P<0.05).After 1 course of treatment and 4 courses of treatment,the iNOS,MDA,HMGB1 and IL-17 in observation group were lower than those in control groups A and B,while the SOD was higher than that in control groups A and B(P<0.05).The scores of MMSE,MoCA,BI,BBS and SF-36 in observation group were higher than those in control groups A and B(P<0.05).Conclusion Rhodiola Rosea assisted nalmefene has a significant effect in the treatment of DEACMP patients,which can reduce oxidative stress response,improve inflammatory and immune homeostasis,balance function and cognitive function,improve quality of life,and has a high safety.

关 键 词：一氧化碳中毒 迟发脑病 免疫-炎症反应轴 氧化应激反应 认知功能 生活质量 安全性 

分 类 号：R595.1[医药卫生—内科学]