重度颈动脉狭窄经吲哚布芬与阿托伐他汀治疗后的CTP成像评价  

Evaluation of CT perfusion imaging for indobufen combined with atorvastatin in the treatment of patients with severe carotid artery stenosis

作　　者：刘冬 张慎和 郭菲 LIU Dong;ZHANG Shenhe;GUO Fei(The First Hospital of Zhangjiakou,Zhangjiakou 075000,China;Hengshui Hospital of Traditional Chinese Medicine,Hengshui 053000,China;Sanhe Yanjiao Fuhe First Hospital,Langfang 065300,China)

机构地区：[1]张家口市第一医院,河北张家口075000 [2]衡水市中医医院,河北衡水053000 [3]三河燕郊福合第一医院,河北廊坊065300

出　　处：《中国实用神经疾病杂志》2023年第9期1113-1117,共5页Chinese Journal of Practical Nervous Diseases

基　　金：2022年度河北医学科学研究课题计划(编号:20221059)。

摘　　要：目的分析脑CT灌注(CTP)成像评价吲哚布芬片联合阿托伐他汀钙片治疗无症状重度颈动脉狭窄(CAS)患者的效果。方法选取2020-01—2022-01张家口市第一医院住院的90例无症状重度CAS患者,采用随机数字表法分为2组,每组45例,对照组给予阿司匹林肠溶片联合阿托伐他汀钙片治疗,观察组给予吲哚布芬片联合阿托伐他汀钙片治疗,对比2组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、颈动脉狭窄程度、CT灌注参数、卒中发生率。结果与对照组(73.33%)相比,观察组临床总有效率(95.56%)明显更高(P<0.05);治疗后观察组患者NIHSS评分、颈动脉狭窄程度均下降,达峰时间(TTP)、平均通过时间(MTT)、脑血容量(CBV)均显著降低,脑血流量(CBF)明显增加,差异均有统计学意义(P<0.05);观察组卒中发生率(0)与对照组(13.33%)比较差异有统计学意义(P<0.05)。结论吲哚布芬片联合阿托伐他汀钙片治疗无症状重度CAS效果显著,可有效减轻颈动脉狭窄程度,降低卒中发生率,CTP成像检查可对治疗效果及颈动脉狭窄程度作出准确评价。Objective To analyze the evaluation value of midbrain CT perfusion(CTP)imaging in patients with asymptomatic severe carotid stenosis(CAS)treated with indobufen tablets combined with atorvastatin calcium tablets.Methods A total of 90 asymptomatic severe CAS patients who were hospitalized in the First Hospital of Zhangjiakou from January 2020 to January 2022 were selected and grouped according to the random number table method,45 patients in each group.The control group was treated with aspirin enteric-coated tablets combined with atorvastatin calcium tablets,and the observation group was treated with indolbuprofen tablets combined with atorvastatin calcium tablets,and the clinical efficacy,National Institutes of Health stroke scale(NIHSS)score,carotid artery stenosis range,CT perfusion parameters,and incidence of stroke were compared between the two groups.Results The clinical total effective rate(95.56%)of the observation group was higher than that of the control group(73.33%,P<0.05).The NIHSS score and the range of carotid artery stenosis in the observation group after treatment were lower than those in the control group.The time to peak(TTP),mean transit time(MTT)and cerebral blood volume(CBV)were lower than those in the control group,the cerebral blood flow(CBF)in the observation group after treatment was higher than that in the control group,the differences were statistically significant(P<0.05).The incidence of stroke(0)in the observation group was lower than that in the control group(13.33%),the difference was statistically significant(P<0.05).Conclusion Indobufen tablets combined with atorvastatin calcium tablets have a significant effect in the treatment of asymptomatic severe CAS,which can effectively reduce the scope of carotid artery stenosis and the incidence of stroke.CT perfusion imaging can accurately evaluate the treatment effect and the degree of carotid artery stenosis.

关 键 词：重度颈动脉狭窄 无症状 脑卒中 吲哚布芬片 阿托伐他汀钙片 脑CT灌注成像 

分 类 号：R543.5[医药卫生—心血管疾病]