五行音乐联合逍遥散干预肺癌患者焦虑行为的临床随机对照研究  

Randomized controlled clinical study of five-element music combined with Xiaoyao Powder in the intervention of anxiety behavior in patients with lung cancer

作　　者：孙晨冰 唐云哲 赵文殊 龚亚斌[1] 焦丽静 刘灏[3] 周平 许玲[1] SUN Chenbing;TANG Yunzhe;ZHAO Wenshu;GONG Yabin;JIAO Lijing;LIU Hao;ZHOU Ping;XU Ling(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Conservatory of Music,Shanghai 200031,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437 [2]上海中医药大学,上海201203 [3]上海音乐学院,上海200031

出　　处：《中华中医药杂志》2023年第7期3499-3504,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：上海市青年科技英才扬帆计划(No.21YF1448200);国家自然科学基金项目(No.82074339);上海市自然基金项目(No.20Z R1459400);第五批全国中医临床优秀人才研修项目(No.RN410.17.06);国家中医药管理局中医药循证能力建设项目(No.2019XZZX-ZL004)。

摘　　要：目的:通过五行音乐联合逍遥散干预肺癌焦虑患者焦虑行为的随机对照研究,评价其疗效及对细胞因子的影响。方法:采用前瞻性、同期、平行、对照的研究设计,纳入患者84例,随机分为治疗组(44例)与对照组(40例),治疗组予以逍遥散联合五行音乐治疗,对照组仅予逍遥散治疗。评价指标为汉密尔顿焦虑量表评分(HAMA),状态-特质焦虑量表(STAI)及外周血细胞因子。结果:治疗后,治疗组HAMA评分显著低于对照组(P<0.05),紧张、失眠、肌肉系统症状、胃肠道症状较对照组显著改善(P<0.05)。治疗组S-AI评分、T-AI评分差值较对照组显著增高(P<0.05)。治疗后治疗组IL-1β、IL-6均显著低于对照组(P<0.05)。结论:五行音乐联合逍遥散可以改善肺癌患者焦虑情绪,可能通过降低IL-1β、IL-6实现。Objective:To evaluate the effect of five-element music combined with Xiaoyao Powder on the anxiety behavior of patients with lung cancer anxiety,and to provide evidence for further clinical application.Methods:A prospective,concurrent,parallel and controlled study design was used to include 84 patients,who were randomly divided into the treatment group(44 cases)and the control group(40 cases).The treatment group was treated with five-element music combined with Xiaoyao Powder,while the control group was treated only with Xiaoyao Powder.The evaluation indexes were Hamilton Anxiety Scale(HAMA),State-trait Anxiety Inventory(STAI)and peripheral blood cytokines.Results:After treatment,HAMA score of the treatment group was significantly lower than that of the control group(P<0.05).Tension,insomnia,muscular system symptoms,gastrointestinal symptoms were significantly improved(P<0.05).The difference of S-AI score and T-AI score in treatment group was significantly higher than that of control group(P<0.05).After treatment,IL-1βand IL-6 in the treatment group were lower than those in the control group(P<0.05).Conclusion:Five-element music combined with Xiaoyao Powder can improve the anxious behavior of lung cancer patients and reduce the level of IL-1βand IL-6.Conclusion:Five-element music combined with Xiaoyao Powder could improve HAMA and S-AI scores of lung cancer patients(P<0.05),and possibly by reducing the levels of interleukin-1β(IL-1β)and interleukin-6(IL-6).

关 键 词：肺癌 焦虑 音乐治疗 中医情志 白介素-1Β 白介素-6 五行 逍遥散 

分 类 号：R248[医药卫生—中医临床基础]