雌二醇及气道杯状细胞黏蛋白5B水平与支气管结核患者炎症情况及临床预后的相关性  

Correlation between estradiol and Mucoprotein 5B in airway Goblet cell with inflammation and clinical prognosis in patients with bronchial tuberculosis

作　　者：张天相 徐红艳 施婕 朱蕾 徐慧 仵倩红 Zhang Tianxiang;Xu Hongyan;Shi Jie;Zhu Lei;Xu Hui;Wu Qianhong(Shaanxi Provincial Hospital of Tuberculosis Prevention and Treatment,Xi’an 710100,China)

机构地区：[1]陕西省结核病防治院,西安710100

出　　处：《中国防痨杂志》2023年第9期885-890,共6页Chinese Journal of Antituberculosis

基　　金：陕西省卫生健康科研基金(2022D044)。

摘　　要：目的:探讨雌二醇及气道杯状细胞黏蛋白5B表达水平与支气管结核患者炎症水平及临床预后的相关性。方法:采用前瞻性研究方法,于2020年6月至2022年6月连续纳入陕西省结核病防治院收治的行支气管镜检查的患者作为研究对象,参照纳入标准分别纳入支气管结核组(112例)和普通肺结核组(62例)。支气管结核组进一步分为溃疡坏死组(54例)和瘢痕狭窄组(58例)。选取同期体检健康志愿者作为正常肺叶组(60名)。分别检测支气管结核组及普通肺结核组抗结核治疗前及治疗1个月后支气管肺泡灌洗液中黏蛋白5B水平及血清雌二醇水平;正常肺叶组仅检测血清雌二醇水平。比较支气管结核组与普通肺结核组抗结核治疗前后黏蛋白5B水平差异,同时比较以上两组抗结核治疗前后与正常肺叶组雌二醇水平差异,并分析支气管结核溃疡坏死组患者黏蛋白5B与雌二醇水平的相关性。结果:治疗前,溃疡坏死组黏蛋白5B水平为(33.39±7.20)μg/L,明显高于瘢痕狭窄组[(17.94±10.61)μg/L]及普通肺结核组[(14.47±5.15)μg/L],差异有统计学意义(t值分别为11.137和16.205,P值均<0.01);溃疡坏死组女性患者黏蛋白5B水平为(32.88±6.97)μg/L。经1个月抗结核治疗后,溃疡坏死组黏蛋白5B水平[(22.86±6.71)μg/L]比治疗前明显降低,差异有统计学意义(t=7.891,P<0.01),也明显高于瘢痕狭窄组[(16.05±5.63)μg/L]及普通肺结核组[(12.67±3.69)μg/L],差异均有统计学意义(t值分别为5.727和9.839,P值均<0.01);溃疡坏死组女性患者黏蛋白5B水平为(22.37±6.57)μg/L。治疗前,溃疡坏死组女性患者雌二醇水平为(120.54±30.66) pmol/L,明显低于瘢痕狭窄组女性患者[(145.31±45.06) pmol/L]、普通肺结核组女性患者[(154.58±51.35) pmol/L]及正常肺叶组女性志愿者[(230.46±76.85) pmol/L],差异均有统计学意义(t值分别为-1.788、-2.854、-8.134,P值分别为0.042、0.016、<0.01)。经1个月抗结核�Objective:To explore the correlation between the expression of estradiol and Mucoprotein 5B in airway Goblet cell and the inflammatory level and clinical prognosis of patients with bronchial tuberculosis.Methods:A prospective cohort study was conducted in the patients who admitted to Shaanxi Provincial Hospital of Tuberculosis Prevention and Treatment from June 2020 to June 2022,and all of them underwent bronchoscopy.According to the inclusion criteria,they were included in the bronchial tuberculosis group(n=112)and the ordinary pulmonary tuberculosis group(n=62).The bronchial tuberculosis group was further divided into ulcer necrosis group(n=54)and scar stenosis group(n=58).A total of 60 healthy volunteers who underwent physical examination during the same period were selected as the normal lung lobe group.The levels of Mucoprotein 5B and serum estradiol in bronchoalveolar lavage fluid(BALF)were measured before and after one month of anti-tuberculosis treatment in the bronchial tuberculosis group and the ordinary pulmonary tuberculosis group,respectively;only serum estradiol levels were detected in the normal lung lobe group.The differences of Mucoprotein 5B level between the bronchial tuberculosis group and the ordinary pulmonary tuberculosis group before and after anti-tuberculosis treatment were compared,and the difference of estradiol level between the two groups before and after anti-tuberculosis treatment and the normal pulmonary lobe group were also compared,to analyze the correlation between Mucoprotein 5B and estradiol level in patients with bronchial tuberculosis ulcer necrosis group.Results:Before treatment,the level of Mucoprotein 5B in the ulcerative necrosis group was(33.39±7.20)μg/L,which was significantly higher than that in the scar stenosis group((17.94±10.61)μg/L,t=11.137,P<0.01)and the ordinary pulmonary tuberculosis group((14.47±5.15)μg/L,t=16.205,P<0.01).The level of Mucoprotein 5B in female patients of ulcerative necrosis group was(32.88±6.97)μg/L.After one month of anti-tuberculos

关 键 词：结核 支气管疾病 支气管肺泡灌洗液 黏蛋白质类 雌二醇 

分 类 号：R523[医药卫生—内科学]