分枝杆菌噬菌体的研究现状及应用进展  

Research status and application progress of mycobacteria phages

作　　者：杜毓 张海鹏[1] 王鹏[1] Du Yu;Zhang Haipeng;Wang Peng(Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention,Yunnan Institute for Endemic Disease Control and Prevention,Dali 671000,China;Public Health School,Kunming Medical University,Kunming 650000,China)

机构地区：[1]云南省地方病防治所,云南省自然疫源性疾病防控技术重点实验室,大理671000 [2]昆明医科大学公共卫生学院,昆明650000

出　　处：《中国防痨杂志》2023年第9期897-903,共7页Chinese Journal of Antituberculosis

基　　金：云南省高层次卫生健康技术人才培养专项(No.L-2019001);云南省产业技术创新人才(YNWR-CYJS-2018-012)。

摘　　要：结核病、麻风病、布鲁里溃疡等一系列分枝杆菌感染性疾病已成为亟待解决的严峻问题,然而耐药分枝杆菌的出现,加剧了临床领域对此类疾病治疗的困难。分枝杆菌噬菌体在分枝杆菌感染引起疾病的诊断与治疗中逐渐彰显出巨大的潜力。笔者对分枝杆菌噬菌体的表型、基因组学及其应用现状等进行归纳总结,为分枝杆菌噬菌体进一步的研究和临床应用提供参考。A series of mycobacterial infectious diseases such as tuberculosis,leprosy and Buruli ulcer have become serious problems to be solved urgently,however,the emergence of drug-resistant mycobacteria has intensified the difficulties in the clinical treatment of such diseases.Mycobacteria bacteriophages has great potential in the diagnosis and treatment of mycobacterium diseases.In this paper,the phenotype,genomics and application status of mycobacteria phages were summarized,to provide reference for further research and clinical application of mycobacteria phages.

关 键 词：分枝杆菌感染 抗药性 分枝杆菌噬菌体 综述文献(主题) 

分 类 号：R183[医药卫生—流行病学]