斑点追踪成像技术探索手术干预对原醛症患者心功能的影响研究  

Study on the effect of surgical intervention on cardiac function in patients with primary aldosteronism by speckle tracking imaging

作　　者：龚丽 陈晓 王妮 沈颖 刘亚男 何博 GONG Li;CHEN Xiao;WANG Ni;SHEN Ying;LIU Yanan;HE Bo(Department of Endocrinology,Jiulongpo Distict People′s Hospital,Chongqing 400050,China;Department of Ultrasound,Jiulongpo Distict People′s Hospital,Chongqing 400050,China;Department of Nephrology,Jiulongpo Distict People′s Hospital,Chongqing 400050,China;Department of Orthopedics,Jiulongpo Distict People′s Hospital,Chongqing 400050,China)

机构地区：[1]重庆市九龙坡区人民医院内分泌科,重庆400050 [2]重庆市九龙坡区人民医院超声科,重庆400050 [3]重庆市九龙坡区人民医院肾内科,重庆400050 [4]重庆市九龙坡区人民医院骨科,重庆400050

出　　处：《现代医药卫生》2023年第16期2772-2775,2788,共5页Journal of Modern Medicine & Health

摘　　要：目的应用超声斑点追踪成像(STI)技术研究手术治疗对原发性醛固酮增多症(PA)患者左、右心室功能的影响。方法回顾性分析2018年10月至2022年2月该院内分泌科收治的55例经手术治疗的PA患者(手术组)和55例年龄、性别及高血压病程相匹配的经药物治疗的PA患者(未手术组)的临床资料,比较2组临床特征及超声心动图数据,以及左、右心室整体纵向收缩期峰值应变(LVGLS、GRVLS)的差异。结果手术组患者术后血压、血浆醛固酮(PAC)水平降低,血钾水平升高;与非手术组相比,手术组患者LVGLS、GRVLS绝对值明显升高,差异均有统计学意义(P<0.05)。结论高PAC水平会导致左、右心室功能出现亚临床损害。手术治疗能纠正大多数PA患者的高血压、高PAC及低血钾状态,同时逆转左、右心室功能的亚临床损害。早期及时诊断并治疗PA能改善患者预后。Objective To evaluate the effect of surgical treatment on left and right ventricular function in patients with primary aldosteronism(PA)by ultrasonic spot tracking imaging(STI).Methods The clinical data of 55 PA patients who underwent surgical treatment(the surgery group)and 55 PA patients who underwent drug treatment(the non-surgery group)matched with age,sex and course of hypertension from October 2018 to February 2022 in the Department of Endocrinology of this hospital were retrospectively analyzed.The clinical characteristics and echocardiographic data were compared between the two groups,as well as the differences of left and right ventricular global longitudinal peak systolic strain(LVGLS,GRVLS)between the two groups.Results The postoperative blood pressure and plasma aldosterone concentrations(PAC)were decreased,and serum potassium level was increased in the surgery group.Compared with the non-surgery group,the absolute values of LVGLS and GRVLS in the surgery group were significantly increased,and the differences were statistically significant(P<0.05).Conclusion High PAC will lead to subclinical damage to left and right ventricular function.Surgical treatment can correct hypertension,high PAC and hypokalemia in most primary aldosteronism patients,and reverse the subclinical damage of the left and right ventricular function.Early and timely diagnosis and treatment of PA can improve patient outcomes.

关 键 词：原发性醛固酮增多症 心功能 斑点追踪成像技术 影响 

分 类 号：R540.45[医药卫生—心血管疾病]