PLZF restricts intestinal ILC3 function in gut defense  

作　　者：Yaru Xu Huasheng Zhang Shuai Wu Jianyue Liu Hongzhi Liu Dongdi Wang Youqin Zhang Hongshen Niu Xiaohui Su Jiping Sun Lei Shen 

机构地区：[1]shanghai Institute of mmunology,Department of Immunology and Microbiology,and Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education,Shanghai Jiao Tong University School of Medicine,Shanghai 20o025,China [2]Shanghai Key Laboratory of Tumor Microenvironment and Inflammation,Shanghai Jjiao Tong University School of Medicine,Shanghai 200025,China [3]Department of Neurosurgery,Center for Immune-Related Diseases at Shanghai lnstitute of Immunology,Rujin Hospital,Shanghai Jjao Tong University School of Medicine,Shanghai 200025,P.R.China.

出　　处：《Cellular & Molecular Immunology》2023年第4期379-388,共10页中国免疫学杂志（英文版）

基　　金：grant 2020YFA0509200(to LS)from the Ministry of Science and Technology of China;grant 81971487(to LS)from the National Natural Science Foundation of China;grants 20ZR1430200 and 20142202300(to LS)from the Science and Technology Commission of Shanghai Municipality;grant 20194Y0275(to JS)from the Shanghai Municipal Health Commission,and the Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases.

摘　　要：Group 3 innate lymphoid cells(ILC3s)play important roles in maintaining intestinal homeostasis by protecting the host from pathogen infections and tissue inflammation.The transcription factor PLZF(promyelocytic leukemia zinc finger),encoded by zinc finger BTB domain containing 16(Zbtb16),is highly and transiently expressed in ILC precursors(ILCPs).However,the role of PLZF in regulating ILC3 development and function remains unknown.Here,we show that PLZF was specifically expressed in mature intestinal ILC3s compared with other ILC subsets.PLZF was dispensable for ILC3 development.However,PLZF deficiency in ILC3s resulted in increased innate interleukin-22(IL-22)secretion and protection against gut infection and inflammation.Mechanistically,PLZF negatively regulated IL-22 expression by ILC3s in a cell-intrinsic manner by binding to the IL-22 promoter region for transcriptional repression.Together,our data suggest that PLZF restricts intestinal ILC3 function to regulate gut immune homeostasis.

关 键 词：Biological sciences IMMUNOLOGY Innate immune cells Innate lymphoid cells 

分 类 号：R392[医药卫生—免疫学]