Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells  

作　　者：Xinping Lv Shan Zhu Jing Wu Jinfeng Shi Qiuyu Wei Tete Li Ning Yang Chunyan Liu Lingli Qi Guoxia Zang Hang Cheng Zhiguang Yang Chengyan Jin Yusheng Wang Jiuwei Cui Hideki Ueno Yong-Jun Liu Jingtao Chen 

机构地区：[1]Cancer Center,First Hospital of Jilin University,Changchun,Jilin 130021,China [2]Laboratory for Tumor Immunology,First Hospital of Jilin University,Changchun,Jilin 130061,China [3]Department of Otolaryngology Head and Neck Surgery,First Hospital of Jilin University,Changchun,Jilin 130021,China [4]Department of Translational Medicine,Changchun GeneScience Pharmaceuticals Co.,Ltd.,Changchun,Jilin 130012,China [5]Department of Gynecology,First Hospital of Jilin University,Changchun,Jilin 130021,China [6]Department of Pediatric Gastroenterology,First Hospital of Jilin University,Changchun,Jilin 130021,China [7]Department of Pediatrics,First Hospital of Jilin University,Changchun,Jilin 130021,China [8]Department of Thoracic Surgery,First Hospital of Jilin University,Changchun,Jilin 130021,China [9]Department of Thoracic Surgery,Second Hospital of Jilin University,Changchun,Jilin 130041,China [10]Department of Immunology,Graduate School of Medicine,Kyoto University,Kyoto,Japan [11]ASHBi Institute for the Advanced Study of Human Biology,Kyoto University,Kyoto,Japan

出　　处：《Cellular & Molecular Immunology》2023年第7期808-819,共12页中国免疫学杂志（英文版）

基　　金：the National Key Research and Development Program(Grant 2021YFF0704800);the Science and Technology Development Program of Jilin Province(Grant 20210402009GH);the Science and Technology Development Program of Jilin Province(Grant YDZJ202201ZYTS098);the Norman Bethune Program of Jilin University(Grant No.2022B34).

摘　　要：Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues.However,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear.Here,we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s.ICOS costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cellindependent B-cell IgA and IgM secretion primarily required CD40 signaling.Hence,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.

关 键 词：Innate lymphoid cell B cell TONSIL ICOS Costimulatory molecule 

分 类 号：R392[医药卫生—免疫学]