咳嗽治疗靶点及其新药研究进展  

Therapeutic targets of cough and research progress of new antitussive drugs

作　　者：姚玥 吴灏 张家硕 苏薇薇[1] 李沛波[1] YAO Yue;WU Hao;ZHANG Jia-shuo;SU Wei-wei;LI Pei-bo(Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM/Guangdong Key Laboratory of Plant Resources,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中山大学生命科学学院广东省中药上市后质量与药效再评价工程技术研究中心/广东省热带亚热带植物资源重点实验室,广州510275

出　　处：《中国新药杂志》2023年第15期1538-1545,共8页Chinese Journal of New Drugs

基　　金：广东省应用型科技研发专项资金项目(2016B020239003);化州市化橘红国家现代农业产业园项目:化橘红产业科技协同创新平台建设。

摘　　要：咳嗽是一种复杂的神经生理反射。咳嗽感受器以受体和离子通道的形式位于气道感觉神经末梢,在受到刺激后产生信号,经迷走神经传入脑干咳嗽中枢,再经传出神经活化相应肌群产生咳嗽。因而,将咳嗽感受器作为咳嗽治疗靶点成为镇咳新药研发的热点。本文介绍了目前咳嗽治疗的靶点以及镇咳新药研发的进展,以期为镇咳新药的研发提供参考。Cough is a complex neurophysiological reflex.Cough receptors are located in the airway sensory nerve endings in the form of receptors and ion channels.After being stimulated,they generate signals that are transmitted to the cough center of the brainstem through the vagus nerve,and then the corresponding muscle group is activated by the efferent nerve to produce cough.Using cough receptors as the targets for the treatment of cough has a bright future.This article introduces the current potential targets for the treatment of cough and the development of new antitussive drugs,hoping to provide reference for the development of antitussive drugs.

关 键 词：咳嗽 靶点 咳嗽感受器 镇咳药物 

分 类 号：R974.2[医药卫生—药品]