不同干燥方法对小承气汤干膏粉化学成分及粉体学性质影响  

Effects of different drying methods on chemical composition and powder properties of Xiaochengqi Decoction dry extract powder

作　　者：郭文慧 单家明 朱文杰 杨武亮 GUO Wen-hui;SHAN Jia-ming;ZHU Wen-jie;YANG Wu-liang(Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《中国新药杂志》2023年第15期1570-1577,共8页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81260612);江西中医药大学中药炮制技术继承与创新团队(CXT22003)。

摘　　要：目的:比较不同干燥方法下得到的小承气汤干膏粉中蒽醌类成分的含量及HPLC指纹图谱相似度;考察不同干燥方法下干膏粉粉体性质,为小承气汤干膏粉的干燥和颗粒制备提供依据。方法:分别采用冷冻、脉动真空、喷雾和减压干燥制备小承气汤干膏粉,测定其游离蒽醌和总蒽醌的含量,比较其HPLC指纹图谱的相似度。同时测定干膏粉的物理性质,并建立其物理指纹图谱,综合评价其粉体学性质。结果:与水煎液中蒽醌类成分含量比较,喷雾干燥、脉动真空干燥得到的干膏粉无显著性差异(P>0.05),减压干燥、冷冻干燥得到的干膏粉存在显著性差异(P<0.05);4种干燥方法下小承气汤干膏粉HPLC指纹图谱相似度均>0.978;物理指纹图谱显示,4种粉体的干燥方法对小承气汤干膏粉粉体学性质存在一定影响;4种粉体的流动性均较差,但喷雾干燥样品具有较好的可压性和均一性,可用于其颗粒的干法制粒。结论:喷雾干燥方法适合小承气汤干膏粉及其颗粒的制备。Objective:The content of anthraquinones in Xiaochengqi Decoction dry extract powder obtained by different drying methods and the similarity of HPLC fingerprint were compared.The properties of dry extract powder under different drying methods were investigated to provide a basis for the drying and particle preparation of Xiaochengqi Decoction dry extract powder.Methods:The Xiaochengqi Decoction dry extract powder was prepared by freezing,pulsating vacuum,spray and vacuum drying,respectively.The contents of free anthraquinone and total anthraquinones in samples using different drying methods were determined,and the similarity of HPLC fingerprints was compared.The physical properties of the dry extract powder were determined,and its physical fingerprint was established to comprehensively evaluate its powder properties.Results:Compared with the content of anthraquinones in the decoction,there was no significant difference in the dry extract powder obtained by spray drying and pulse vacuum drying(P>0.05),but there was significant difference in the dry paste powder obtained by vacuum drying and freeze drying(P<0.05).The similarity of HPLC fingerprints of Xiaochengqi decoction dry extract powder under the four drying methods were all above 0.978.The physical fingerprints showed that the four drying methods had a certain effect on the powder properties of Xiaochengqi Decoction dry extract powders.The fluidity of the four powders is poor,but the spray⁃dried samples have good compressibility and uniformity,which can be used for dry granulation of their particles.Conclusion:The spray drying method is suitable for the preparation of Xiaochengqi Decoction dry extract powder and its granules.

关 键 词：小承气汤 干燥方法 含量测定 HPLC指纹图谱 物理指纹图谱 粉体学性质 

分 类 号：R943.42[医药卫生—药剂学] R979.1[医药卫生—药学]