血清CX3CR1在冠状动脉狭窄性疾病诊断及PCI预后中的评估作用  

Role of serum CX3CR1 in the diagnosis of coronary artery stenosis and in the evaluation of prognosis after percutaneous coronary intervention

作　　者：林娟娟 黄伟洁 吴荣宝 高茵 Lin Juanjuan;Huang Weijie;Wu Rongbao;Gao Yin(Department of Cardiology,Haiyang People's Hospital,Haiyang 265100,Shandong Province,China)

机构地区：[1]海阳市人民医院心内科,海阳265100

出　　处：《中国基层医药》2023年第8期1154-1159,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨血清单核细胞CX3C趋化因子受体(CX3CR1)在冠状动脉狭窄性疾病诊断及对经皮冠状动脉介入治疗(PCI)预后的评估作用。方法选取2018年1月至2019年5月于海阳市人民医院经冠状动脉造影(CAG)确诊冠状动脉血管狭窄≥50%并行PCI治疗且随访至2021年5月的冠状动脉狭窄性疾病患者101例为研究对象(观察组),选取同期健康体检者34例设为对照组,并根据末次随访结果将观察组患者分为术后支架内再狭窄(ISR)组(n=28)、非ISR组(n=73)。检测CX3CR1表达量,统计心脏不良事件发生率,评估CX3CR1诊断冠状动脉狭窄性疾病和预测心脏不良事件发生率的曲线下面积(AUC)、敏感度、特异度。结果观察组CX3CR1表达量为(3.95±1.05)μg/L,高于对照组的(2.30±0.65)μg/L(t=2.87,P<0.05)。受试者工作特征曲线(ROC)分析显示,CX3CR1诊断冠状动脉狭窄性疾病的AUC为0.892,敏感度为75.2%、特异度88.2%。ISR组非致死性心肌梗死、心绞痛、心力衰竭、心源性死亡等发生率均高于非ISR组(χ^(2)=8.06、7.17、8.06、7.17,均P<0.05)。ROC曲线分析显示,CX3CR1预测非致死性心肌梗死、心绞痛、心力衰竭、心源性死亡的AUC值分别为0.786、0.895、0.997、0.887。结论CX3CR1在冠状动脉狭窄性疾病中呈高表达,能为其诊断和预后评估提供参考。Objective To investigate the role of serum CX3CR1 in the diagnosis of coronary artery stenosis and in the evaluation of prognosis after percutaneous coronary intervention.Methods A total of 101 patients with coronary artery stenosis(≥50%stenosis)confirmed with coronary angiography(CAG)in Haiyang People's Hospital from January 2018 to May 2019 who were followed up till May 2021 were included in the observation group.Thirty-four healthy individuals who underwent physical examination during the same period were included in the control group.Patients in the observation group were divided into an in-stent restenosis group(ISR group,n=28)and a non-ISR group(n=73).The expression of CX3CR1 was detected.The incidence of adverse cardiac events was calculated.The sensitivity,specificity,and area under the curve(AUC)plotted for the use of CX3CR1 to diagnose coronary artery stenosis and predict adverse cardiac events were evaluated.Results The expression of CX3CR1 in the observation group was(3.95±1.05)μg/L,which was significantly higher than(2.30±0.65)μg/L in the control group(t=2.87,P<0.05).The receiver operating characteristic curve analysis showed that the AUC,sensitivity,and specificity of the use of CX3CR1 in diagnosing coronary artery stenosis were 0.892,75.2%,and 88.2%.The incidence of non-fatal myocardial infarction,angina pectoris,heart failure,and cardiac death in the ISR group was significantly higher compared with the non-ISR group(χ^(2)=8.06,7.17,8.06,7.17,all P<0.05).The receiver operating characteristic curve analysis results showed that the AUC value of CX3CR1 in predicting non-fatal myocardial infarction,angina pectoris,heart failure,and cardiac death were 0.786,0.895,0.997,and 0.887,respectively.Conclusion CX3CR1 is highly expressed in coronary artery stenosis,which can provide a reference for the diagnosis and prognostic evaluation of coronary artery stenosis.

关 键 词：趋化因子 CX3C 受体 趋化因子 单核细胞 冠状动脉狭窄 经皮冠状动脉介入治疗 移植物闭塞 血管 心肌梗死 心绞痛 心力衰竭 猝死 心脏 

分 类 号：R541.4[医药卫生—心血管疾病]