羟丙基壳聚糖/氧化甲基纤维素自愈合水凝胶的制备及其载药性能  

Preparation and drug loading properties of hydroxypropyl chitosan/oxidized methyl cellulose self-healing hydrogel

作　　者：曲萌菲 王艺璇 张杭 李征征 QU Mengfei;WANG Yixuan;ZHANG Hang;LI Zhengzheng(College of Chemical Engineering and Materials Science,Tianjin University of Science&Technology,Tianjin 300457,China;State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 200433,China)

机构地区：[1]天津科技大学化工与材料学院,天津300457 [2]复旦大学聚合物分子工程国家重点实验室,上海200433

出　　处：《精细化工》2023年第8期1734-1741,共8页Fine Chemicals

基　　金：2021年天津市研究生科研创新项目(2021YJSS048);2018年度天津市教委科研计划项目(2018KJ110)。

摘　　要：采用高碘酸钠对甲基纤维素(MC)进行氧化制备了氧化甲基纤维素(DAMC),通过羟丙基壳聚糖(HPC)的氨基与DAMC的醛基发生希夫碱反应制备了HPC/DAMC自愈合水凝胶。通过调节HPC和DAMC含量探究水凝胶的微观形态、溶胀性能、力学性能、自愈合性能、体外降解以及药物缓释性能。结果表明,HPC/DAMC自愈合水凝胶具有相互连通的孔隙,且孔径处于80~375μm范围内,在室温无刺激条件下能够在20 min内实现自愈合且具有良好的拉伸性能。此外,HPC/DAMC自愈合水凝胶具有良好的保水性,其溶胀比为14.0~17.4。在溶菌酶的作用下,HPC/DAMC自愈合水凝胶在60 h时质量损失率可达84.2%~99.6%。HPC/DAMC自愈合水凝胶对抗肿瘤药物吉西他滨具有缓释效果,缓释作用长达96 h,药物累积释放率达到83.2%~92.7%。Hydroxypropyl chitosan/oxidized methyl cellulose(HPC/DAMC)hydrogel with self-healing properties was synthesized by chemical cross-linking Schiff base reaction between the amino group in HPC and the aldehyde group in DAMC,which was obtained from oxidization of methyl cellulose with sodium periodate.The micromorphology,swelling properties,mechanical properties,self-healing properties,in vitro degradation properties and sustained-release properties of the hydrogels prepared were investigated by adjusting the content of HPC to DAMC.The results showed that HPC/DAMC self-healing hydrogel had interconnected pores with size ranging from 80 to 375μm.The hydrogel,with good ensile property,could achieve self-healing in 20 min at room temperature without external stimulation.Meanwhile,the hydrogels exhibited good water retention with swelling ratios of 14.0~17.4.The hydrogels displayed mass loss rates of 84.2%~99.6%at 60 h with lysozyme.Furthermore,HPC/DAMC hydrogels showed a sustained release effect on anticancer drug gemcitabine up to 96 h,with cumulative drug release rates of 83.2%~92.7%.

关 键 词：羟丙基壳聚糖 自愈合 亚胺键 水凝胶 药物释放 功能材料 

分 类 号：TQ427.26[化学工程] TQ460.4