Cu(Ⅱ)配合物的制备、结构多样性及超氧化物歧化酶活性  

Preparation,structural diversity and superoxide dismutase activity of Cu(Ⅱ)coordination polymers

作　　者：张文谦 牛亚杰 吴文荣 常笑玮 王东飞 张帅 ZHANG Wenqian;NIU Yajie;WU Wenrong;CHANG Xiaowei;WANG Dongfei;ZHANG Shuai(School of Pharmaceutical Engineering,Xinyang Agricultural and Forestry University,Xinyang 464000,Henan,China)

机构地区：[1]信阳农林学院制药工程学院,河南信阳464000

出　　处：《精细化工》2023年第8期1749-1757,共9页Fine Chemicals

基　　金：河南省科技攻关项目(212102310343);信阳农林学院高水平科研孵化器建设基金资助项目(FCL202008)。

摘　　要：为了构筑超氧化物歧化酶(SOD)模拟物,采用溶剂热法,以吡啶-3-羧酸-1-氧(HL1)和吡啶-4-羧酸-1-氧(HL2)为有机配体,与一水合醋酸铜〔Cu(OAc)_(2)·H_(2)O〕金属盐反应合成了3种Cu(Ⅱ)的配合物(CPs):[Cu_(3)(HL1)_(4)(OH)2(H_(2)O)2]n(CP1)、[Cu(HL2)(OH)]n(CP2)和[Cu(HL2)(CH_(3)O)]_(n)(CP3),其中n为正整数。通过单晶XRD、FTIR、元素分析、TGA、UV光谱对其进行了结构和性能表征。CP1~3在相似的溶剂热条件下合成,却分别显示出一维、二维到三维的多维度构型,探讨了配体官能团的相对位置、配体的配位模式和溶剂体系在配合物的结构多样性方面的可能机制。TGA表明,CP1~3可以分别稳定到202、228、250℃,具有较好的热稳定性,且CP1~3的维度越高,热稳定性越好。通过氯化硝基四氮唑蓝(NBT)光还原法测试得出,CP1~3的半数抑制浓度(IC50)分别为0.21、0.26、0.62μmol/L,均具有一定的SOD活性,且CP1~3的维度越低,SOD活性越好。其中,CP1和CP2较低的IC50表明其可作为有潜在应用前景的SOD模拟物。To construct superoxide dismutase(SOD)mimetics,three Cu(Ⅱ)coordination polymers(CPs),[Cu_(3)(HL1)_(4)(OH)2(H_(2)O)2]n(CP1),[Cu(HL2)(OH)]n(CP2)and[Cu(HL2)(CH_(3)O)]_(n)(CP3),in which n is a positive integer,were synthesized from solvothermal reaction of pyridyl-3-carboxylic acid-1-oxide(HL1)or pyridyl-4-carboxylic acid-1-oxide(HL2)with copper acetate monohydrate[Cu(OAc)_(2)•H_(2)O].The CPs obtained were then characterized by single crystal XRD,FTIR,elemental analysis,TGA and UV spectroscopy for structure and property analyses.The results showed that CP1~3,though synthesized under similar solvothermal conditions,exhibited a multi-dimensional configurations from one-dimension,two-dimension to three-dimension,respectively.The possible mechanisms of the relative position of functional groups in ligand,the coordination mode of ligand and the solvent system on the structural diversity of CPs were also explored.TGA result revealed that CP1~3 could be stabilized up to 202,228,and 250℃,respectively,displaying good thermal stability,and the thermal stability improved as the dimension increased.Nitrotetrazolium blue chloride(NBT)photoreduction test indicated that the median inhibition concentration(IC50)values of CP1~3 were 0.21,0.26 and 0.62μmol/L,respectively,showing certain SOD activity which was enhanced as the dimension decreased.The lower IC50 of CP1 and CP2 suggested that they could be used as potential SOD mimetics.

关 键 词：铜(Ⅱ)配合物 吡啶-3-羧酸-1-氧 吡啶-4-羧酸-1-氧 SOD活性 功能材料 

分 类 号：O641[理学—物理化学]