脂联素在糖尿病视网膜病变发病机制中作用的研究进展  

Progress in the role of adiponectin in the pathogenesis of diabetic retinopathy

作　　者：吴贤俊 周琼[1] Wu Xianjun;Zhou Qiong(Department of Ophthalmology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院眼科,南昌330006

出　　处：《中华眼底病杂志》2023年第8期708-713,共6页Chinese Journal of Ocular Fundus Diseases

基　　金：江西省重点研发计划(20192BBGL70033,20203BBG73058)。

摘　　要：糖尿病视网膜病变(DR)是糖尿病引起的常见的典型微血管病变并发症之一,是严重且常见的致盲性眼部并发症。DR的具体发病机制目前尚未完全明确,其发生发展过程中涉及多种因素。脂联素(APN)是由脂肪细胞分泌的一种内源性细胞因子,在视网膜全层均有表达,特别是在外层(视杆细胞及视锥细胞层)表达更加明显,其与特异性受体结合参与调节脂肪酸氧化和糖代谢等过程。近年许多研究发现APN可以参与调节机体血糖、抑制新生血管生成、减轻炎症反应、舒张血管及改善血管内皮功能等。然而,有关APN在DR发生发展中的具体机制尚无定论,其在DR中的水平变化及具体作用机制的进一步研究可能有助于识别DR的特征性代谢变化,从而为DR的诊断提供新的生物标志物,同时有助于推进DR的治疗的革新。Diabetic retinopathy(DR)is one of common and specific microvascular complications caused by diabetic mellitus,and remains a serious and common ocular complication leading preventable blindness.At present,the specific pathogenesis of DR is not completely clear,and many factors are involved in its occurrence and development.Adiponectin(APN)is an endogenous cytokine secreted by adipocytes.It is expressed in all layers of retina,especially in the outer layer(rods and cones).It is involved in regulating fatty acid oxidation and glucose metabolism by binding with specific receptors.In recent years,a lot of studies have found that APN can be involved in regulating blood glucose,inhibiting neovascularization,reducing inflammation,dilating blood vessels and improving vascular endothelial function.At present,the specific mechanism of APN in the occurrence and development of DR Remains to be determined.Further research on the level changes and the specific mechanism of action of APN in DR may help to identify the characteristic metabolic changes of DR,thus providing new biomarkers for the diagnosis of DR,while helping to promote the innovation of the treatment of DR.

关 键 词：脂联素 糖尿病视网膜病变 发病机制 综述 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]