Insight into Biophysicochemical Principles of Biopolymers through Simulation and Theory  

作　　者：Hai-Xiao Wan Duo Xu Xue-Wei Dong Kai Yang Li-Tang Yan 

机构地区：[1]State Key Laboratory of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing,100084,China [2]Center for Soft Condensed Matter Physics and Interdisciplinary Research&School of Physical Science and Technology,Soochow University,Suzhou,215006,China

出　　处：《Chinese Journal of Polymer Science》2023年第9期1342-1354,I0005,共14页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.22025302,21873053 and 32230063);financial support from the open research fund of Songshan Lake Materials Laboratory(No.2021SLABFK10)。

摘　　要：The development of biopolymers for biomedical applications has traditionally been based on new chemistries.However,there is growing recognition that the biological responses can be regulated by the physical as well as the chemical properties of biomaterials.Understanding the biophysicochemical principles regarding biopolymers is thereby of great importance in the generation of advanced biomaterials.Herein,this review article seeks to provide a conceptual framework demonstrating how the approaches of tailored computer simulations and theoretical analysis are harnessed to explore the physicochemical principles of biopolymer cellular interactions.We briefly introduce the theoretical and simulation methods used in this field,summarize the typical findings based on these approaches,and describe the correlations between theoretical results and experiments.Finally,the future prospects for the theoretical aspect of biopolymers and their biophysicochemical interactions are discussed.The knowledge might be critical from the perspective of advantageous and safe use of designer biomaterials.

关 键 词：Biopolymers Computer simulation Theoretical analysis Biophysicochemical interaction BIOPHYSICS 

分 类 号：TQ317[化学工程—高聚物工业] R318[医药卫生—生物医学工程]