妊娠期肝内胆汁淤积症孕妇血清总胆酸水平和胎儿心脏功能的相关性  

Correlation between Serum Total Cholic Acid Levels and Fetal Cardiac Function in Pregnant Women with Intrahepatic Cholestasis of Pregnancy

作　　者：陈慧[1] CHEN Hui(Obstetrics and Gynecology Department,Suixian Maternal and Child Health Hospital,Shangqiu Henan 476900,Chian)

机构地区：[1]睢县妇幼保健院产科,河南商丘476900

出　　处：《临床研究》2023年第9期44-46,共3页Clinical Research

摘　　要：目的探讨妊娠期肝内胆汁淤积症孕妇血清总胆酸水平和胎儿心脏功能的相关性。方法选择2021年1月至2022年12月在睢县妇幼保健院妇产科接诊的130例妊娠期肝内胆汁淤积症孕产妇(观察组)及同时间段在该医院妇产科实施检查的130例健康孕产妇(对照组)的数据资料实施回顾性分析。比较两组孕产妇的血清总胆酸、丙氨酸基转氨酶、γ-谷氨酰转肽酶水平。比较两组孕产妇的围产儿不良结局情况(早产、羊水粪染、宫内窘迫)。比较两组新生儿的脐带血心肌肌钙蛋白Ⅰ(cTnⅠ)、胎儿左心室Tei指数。分析孕产妇血清总胆酸和新生儿的脐带血cTnⅠ、胎儿左心室Tei指数的相关性。结果观察组孕产妇的血清总胆酸、丙氨酸基转氨酶、γ-谷氨酰转肽酶水平均显著高于对照组,差异有统计学意义(P<0.05)。观察组孕产妇的围产儿不良结局发生率均高于对照组,差异有统计学意义(P<0.05)。观察组新生儿的脐带血cTnⅠ、胎儿左心室Tei指数均显著高于对照组,差异有统计学意义(P<0.05)。孕产妇血清总胆酸和新生儿的脐带血cTnⅠ、胎儿左心室Tei指数均呈正相关,差异有统计学意义(r=0.683,0.573,P<0.05)。结论妊娠期肝内胆汁淤积症孕妇的血清总胆酸水平明显增高,血清总胆酸水平同胎儿心脏功能之间也具有密切的相关性。增高的胆酸会对胎儿心肌构成损伤,因此需要对孕妇给予重点关注。Objective To investigate the correlation between serum total cholic acid level and fetal cardiac function in pregnant women with intrahepatic cholestasis of pregnancy.Methods The data of 130 pregnant women with intrahepatic cholestasis of pregnancy who were admitted to the obstetrics and gynecology department of Suixian Maternal and Child Health Hospital from January 2021 to December 2022(observation group)and 130 healthy pregnant women who underwent examination in the obstetrics and gynecology department of the hospital during the same period(control group)were retrospectively analyzed.The serum levels of total cholic acid,alanine aminotransferase and gamma-glutamyl transpeptidase were compared between the two groups.Compare the adverse perinatal outcomes(premature delivery,meconium stained amniotic fluid,and intrauterine distress)between two groups of pregnant women The cord-blood cardiac troponinⅠ(cTnⅠ)and fetal left ventricular Tei index were compared between the two groups.To analyze the correlation between maternal serum total cholic acid and neonatal cord blood cTnⅠand fetal left ventricular Tei index.Results The serum levels of total cholic acid,alanine aminotransferase andγ-glutamyl transpeptidase in observation group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).The incidence of adverse perinatal outcomes in the observation group was higher than that in control group,and the difference was statistically significant(P<0.05).Neonatal cord blood cTnⅠand fetal left ventricular Tei index in observation group were significantly higher than those in control group,and the difference was statistically significant(P<0.05).There was a positive correlation between serum total cholic acid and neonatal cord blood cTnⅠand fetal left ventricular Tei index,and the difference was statistically significant(r=0.683,0.573,P<0.05).Conclusion The serum total cholic acid level in pregnant women with intrahepatic cholestasis of pregnancy is significantl

关 键 词：妊娠期肝内胆汁淤积症 孕妇 血清总胆酸 胎儿 心脏功能 肌钙蛋白Ⅰ 

分 类 号：R714.255[医药卫生—妇产科学]