盐酸异丙嗪联合维生素B_(1)肌肉注射治疗妊娠剧吐孕妇的临床疗效及对孕妇临床症状和尿酮体与胃动素水平的影响  

Clinical efficacy of promethazine hydrochloride combined with vitamin B1 intramuscular injection in the treatment of pregnant women with hyperemesis gravidarum and its influence on the clinical symptoms,urinary ketone body and motilin levels of pregnant women

作　　者：安舒 AN Shu(Department of Obstetrics and Gynecology,Fang Dazhong(Yingkou)Hospital Co.,Ltd.,Yingkou,Liaoning,115000,China)

机构地区：[1]方大群众(营口)医院有限公司妇产科,辽宁营口115000

出　　处：《当代医学》2023年第6期47-50,共4页Contemporary Medicine

基　　金：辽宁省科技厅自然基金指导计划(2019-ZD-0967)。

摘　　要：目的分析盐酸异丙嗪联合维生素B1肌肉注射对妊娠剧吐孕妇临床症状、尿酮体(KET)和胃动素(MOT)水平的影响。方法选取2017年9月至2020年5月本院接收的82名妊娠剧吐孕妇作为研究对象,按照随机数字表法分为实验组与对照组,每组41名。对照组予以5%碳酸氢钠+10%葡萄糖+维生素B6治疗,实验组予以盐酸异丙嗪联合维生素B1肌肉注射治疗。比较两组临床疗效、症状改善时间、KET和MOT水平、妊娠专用恶心呕吐量化表(PUQE)和妊娠恶心呕吐生命质量量表(NVPQOL)评分及不良反应发生情况。结果实验组治疗总有效率为95.12%,高于对照组的75.61%,差异有统计学意义(P<0.05)。实验组酮体转阴时间、电解质恢复正常时间、恶心呕吐时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,实验组KET水平低于对照组,MOT水平高于对照组,差异有统计学意义(P<0.05)。治疗后,实验组PUQE、NVPQOL评分均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论盐酸异丙嗪联合维生素B1肌肉注射治疗妊娠剧吐孕妇疗效显著,可有效缩短症状改善时间,下调KET、MOT水平,改善呕吐症状,提高其生命质量,值得临床推广应用。Objective To analyze the effects of promethazine hydrochloride combined with vitamin B1 intramuscular injection on clinical symptoms,urinary ketone body(KET)and motilin(MOT)levels in pregnant women with hyperemesis gravidarum.Methods 82 pregnant women with hyperemesis gravidarum received in our hospital from September 2017 to May 2020 were selected as the research subjects,and they were divided into the experimental group and the control group according to the random number table method,with 41 cases in each group.The control group was treated with 5%sodium bicarbonate+10%glucose+vitamin B6,and the experimental group was treated with promethazine hydrochloride and vitamin B1 intramuscular injection.The clinical efficacy,symptom improvement time,urinary KET and MOT levels,pregnancy-unique quantification of emesis and nausea(PUQE)and nausea and vomiting of preg-nancy quality of life(NVPQOL)scores and adverse reactions were compared between the two groups.Results The total effective rate in the experimental group was 95.12%,which was higher than 75.61%in the control group,and the difference was statistically significant(P<0.05).The ketone body to turn negative time,electrolyte to return to normal time,nausea and vomiting time in the experimental group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the KET level in the experimental group was lower than that in the control group,and the MOT level was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the PUQE and NVPQOL scores in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Promethazine hydrochloride combined with vitamin B1 intramuscular injection has significant effect on pregnant women with hyperemesis gravidarum,which can effectively shorten the tim

关 键 词：妊娠剧吐 维生素B1 盐酸异丙嗪 尿酮体 胃动素 不良反应 

分 类 号：R714[医药卫生—妇产科学]