缺血性脑卒中的线粒体质量控制与铁死亡关联机制及中医药干预研究进展  

Research progress on the correlation mechanism between mitochondrial quality control and ferroptosis in ischemic stroke and the TCM intervention

作　　者：韦梦真 刘丹红 曾劲松 方锐[1] 梅志刚 葛金文[1] 廖君[1] WEI Mengzhen;LIU Danhong;ZENG Jinsong;FANG Rui;MEI Zhigang;GE Jinwen;LIAO Jun(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2023年第8期1522-1530,共9页Journal of Hunan University of Chinese Medicine

基　　金：湖南省自然科学基金项目(2021JJ30496,2021JJ30499);湖南省中医药管理局重点指导项目(C2023003);湖南中医药大学研究生创新课题(2022CX178);国家级大学生创新创业课题一般项目(202110541075);湖南省中医药科研课题(B2023025),湖南中医药大学校级科研基金项目(2021XJJJ022)。

摘　　要：缺血性脑卒中(ischemic stroke,IS)是一个复杂的级联过程,对大脑产生不可逆的损伤,严重危害人类健康。铁死亡是铁依赖及脂质过氧化物生成所致的一种细胞死亡方式,是IS的一个重要病理表现。线粒体是真核生物进行氧化代谢的细胞器,是糖类、脂肪和氨基酸最终氧化释放能量的场所。线粒体质量控制(mitochondrial quality control,MQC)是一个内源性调控机制,作为氧化代谢的主要调节器和铁利用的主要场所,MQC与铁死亡密切关联。稳定MQC是抑制铁死亡保护IS的重要治疗机制。系统介绍在IS中MQC与铁死亡关联机制,为IS发生机制研究和临床药物靶点提供新思路。Ischemic stroke(IS)is a complex cascade process,which causes irreversible damage to the brain and seriously endangers human health.Ferroptosis is a form of cell death caused by iron-dependence and lipid peroxide generation,and is an important pathological manifestation of IS.Mitochondria are eukaryotic organelles for oxidative metabolism,and are the sites where sugars,fats and amino acids eventually oxidize and release energy.Mitochondrial quality control(MQC)is an endogenous regulatory mechanism.As the main regulators of oxidative metabolism,mitochondria are also the main sites of iron utilization,so MQC is closely correlated with ferroptosis.Stabilizing MQC is an important therapeutic mechanism for inhibiting ferroptosis and protecting the body from IS.This article systematically introduces the correlation mechanism between MQC and ferroptosis in IS to provide new ideas for the study of IS pathogenesis and clinical drug targets.

关 键 词：缺血性脑卒中 线粒体质量控制 线粒体自噬 线粒体动力学 线粒体生物合成 铁死亡 中医药干预 

分 类 号：R255[医药卫生—中医内科学]