天然药物中抗乙型肝炎病毒活性成分研究进展  

Research progress on active ingredients of anti-hepatitis B virus in natural medicines

作　　者：孙伍慧 姚思凡 张艺 赵碧清[1] SUN Wuhui;YAO Sifan;ZHANG Yi;ZHAO Biqing(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2023年第8期1536-1546,共11页Journal of Hunan University of Chinese Medicine

基　　金：湖南省教育厅科学研究项目(19K067);湖南中医药大学中药学一流学科项目(2018ZYX01)。

摘　　要：乙型肝炎病毒(hepatitis B virus,HBV)是引起乙型肝炎的病原体,具有传染性强、发病率高和流行范围广等特点,严重威胁着人类的健康。目前临床使用的药物存在着较大缺陷,迫切需要更为高效安全的抗HBV新药,研究天然药物及其活性成分抗HBV已经成为一种趋势。通过查阅近十年文献,对天然药物中抗HBV活性单体成分的研究概况进行整理,按化学类别分类,总结出97个活性显著、靶点独特的天然药物活性成分及衍生物,主要包括苯丙素类、黄酮类、生物碱类、萜类等,并对HBV的感染与抑制机制进行归纳。旨在阐述抗HBV活性成分的新发现,为今后开发新的抗HBV药物提供参考。As the pathogen of hepatitis B,hepatitis B virus(HBV)is characterized by strong infectivity,high morbidity,and wide prevalence,which seriously threatens human health.Currently,there are significant deficiencies in the clinical use of drugs against it,and more efficient and safer new anti-HBV drugs are urgently needed.It has become a trend to study natural medicines and their active ingredients against HBV.By consulting the literature in the past decade,the research progress on the active ingredients of anti-HBV in natural medicines was reviewed.According to chemical categories,97 active ingredients and derivatives of natural medicines with notable activity and unique targets were summarized,mainly including phenylpropanoids,flavonoids,alkaloids,terpenoids,and others.Meanwhile,the mechanisms of HBV infection and inhibition were also summarized.This paper aims to elaborate the new findings of anti-HBV active ingredients and provide reference for the development of new anti-HBV drugs in the future.

关 键 词：天然药物 抗乙型肝炎病毒 活性成分 作用机制 研究进展 

分 类 号：R284[医药卫生—中药学]