单孔胸腔镜手术治疗自发性气胸对患者氧化应激反应及生化指标的影响  

Effects of single-aperture thoracoscopy surgery on oxidative stress response and biochemical indexes in patients with spontaneous pneumothorax

作　　者：张爱军[1] 刘庆余[1] 张继新 ZHANG Aijun;LIU Qingyu;ZHANG Jixin(Department of Thoracic Surgery,the Third Hospital of Tangshan,Tangshan,Hebei,063000,China)

机构地区：[1]唐山市第三医院胸外科,河北唐山063000

出　　处：《当代医学》2023年第10期9-13,共5页Contemporary Medicine

摘　　要：目的探究采用单孔胸腔镜手术治疗自发性气胸的临床疗效。方法选取2019年2月至2021年2月本院收治的80例自发性气胸患者作为研究对象,随机分为两组,每组40例。研究组采用单孔胸腔镜术,对照组采用传统三孔胸腔镜术,比较两组手术前后氧化应激反应和生化指标及生命质量、手术情况及并发症发生情况。结果两组血清超氧化物歧化酶(SOD)、血清丙二醛(MDA)水平组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:术后1、术后3 d,两组SOD水平均低于术前,但术后3 d高于术后1 d,差异有统计学意义(P<0.05);术后1、3 d,两组MDA水平均高于术前,但术后3 d低于术后1 d,差异有统计学意义(P<0.05)。组间比较:术前,两组SOD、MDA水平比较差异无统计学意义;术后1、3 d,研究组SOD水平均高于对照组,MDA水平均低于对照组,差异有统计学意义(P<0.05)。研究组手术时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。两组血清中P物质(SP)、神经肽Y(NPY)、前列腺素E_(2)(PGE_(2))水平组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:术后1、3 d,两组NPY、SP、PGE_(2)水平均高于术前,但术后3 d低于术后1 d,差异有统计学意义(P<0.05)。组间比较:术前,两组NPY、SP、PGE_(2)水平比较差异无统计学意义;术后1、3 d,研究组NPY、SP、PGE_(2)水平均低于对照组,差异有统计学意义(P<0.05)。术前,两组圣乔治呼吸问卷(SGRQ)评分比较差异无统计学意义;术后3个月,两组SGRQ评分低于术前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率为2.50%,低于对照组的20.00%,差异有统计学意义(P<0.05)。结论单孔胸腔镜手术治疗自发性气胸效果确切,可降低患者氧化应激反应及并发症发生率,减轻疼痛,改善术后生命质量,促进术后康复,值得临床推广应用。Objective To explore the clinical effect of single-aperture thoracoscopy surgery in the treatment of spontaneous pneumothorax.Methods 80 patients with spontaneous pneumothorax admitted to our hospital from February 2019 to February 2021 were selected as the research subjects,and they were randomly divided into two groups,with 40 cases in each group.The study group used single-aperture thoracoscopy and the control group used traditional three-aperture thoracoscopy,the oxidative stress reaction and biochemical indexes,quality of life before and after surgery,operation and complications were compared between the two groups.Results There were significant differences in superoxide dismutase(SOD)and maleic dialdehyde(MDA)levels between the two groups of group,time points and interaction(P<0.05).Comparison on within the group:at 1 and 3 d after operation,the SOD levels of the two groups were lower than those before operation,but at 3 d after operation,the SOD levels were higher than those at 1 d after operation,and the differences were statistically significant(P<0.05).At 1 and 3 d after operation,the MDA levels of the two groups were higher than those before operation,but the MDA level at 3 d after operation was lower than that at 1 d after operation,and the differences were statistically significant(P<0.05).Comparsion between groups:before operation,there were no significant differences in the levels of SOD and MDA between the two groups;at 1 and 3 d after operation,the SOD levels in the study group were higher than those in the control group,and the MDA levels were lower than those in the control group,and the differences were statistically significant(P<0.05).The operation time and hospital stay in the study group were shorter than those in the control group,and the amount of intraoperative blood loss was less than that of the control group,the differences were statistically significant(P<0.05).There were significant differences in the levels of neuropeptide Y(NPY),substance P(SP)and prostaglandin E_(2)(PGE_(2))betw

关 键 词：自发性气胸 单孔胸腔镜术 氧化应激反应 前列腺素E2 血清神经肽Y 

分 类 号：R655[医药卫生—外科学]