阿奇霉素干混悬剂联合布拉氏酵母菌治疗儿童感染性腹泻的临床疗效观察  

Clinical efficacy of azithromycin dry suspension combined with Saccharomyces boulardii in the treatment of infectious diarrhea in children

作　　者：刘祎[1] 张娜[1] 邓添[1] 黄应希[1] LIU Yi;ZHANG Na;DENG Tian;HUANG Yingxi(Department of Pediatrics,the Second Affiliated Hospital of Yichun University,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春学院第二附属医院儿科,江西宜春336000

出　　处：《当代医学》2023年第10期58-61,共4页Contemporary Medicine

摘　　要：目的探究阿奇霉素干混悬剂联合布拉氏酵母菌治疗儿童感染性腹泻的临床疗效。方法选取2018年12月至2020年12月本院收治的78例感染性腹泻患儿作为研究对象,按照随机数表法分为观察组与对照组,每组39例。两组均给予常规治疗,对照组给予布拉氏酵母菌治疗,观察组给予阿奇霉素干混悬剂和布拉氏酵母菌散剂及蒙脱石散治疗,比较两组临床疗效、不同时间点平均便次、腹泻持续时间、痊愈时间、治疗前后血清炎症指标[白细胞介素-8(IL-8)、白细胞介素-10(IL-10)及C反应蛋白(CRP)]及不良反应发生情况。结果观察组治疗总有效率为94.87%,高于对照组76.92%,差异有统计学意义(P<0.05)。两组平均便次组间、时间、交互比较差异有统计学意义;组内比较:两组治疗后各时间点平均便次均少于前一时间点,差异有统计学意义(P<0.05)。组间比较:治疗前,两组平均便次比较差异无统计学意义;治疗1、3、7 d后,观察组平均便次均少于对照组,差异有统计学意义(P<0.05)。观察组腹泻持续时间和痊愈时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-8、IL-10和CRP水平比较差异无统计学意义;治疗后,两组IL-8、CRP水平均低于治疗前,IL-10水平高于治疗前,且观察组IL-8、CRP水平均低于对照组,IL-10水平高于对照组,差异有统计学意义(P<0.05)。两组均未发生腹痛腹泻、恶心呕吐、稀便等不良反应。结论阿奇霉素干混悬剂联合布拉氏酵母菌治疗儿童感染性腹泻的临床疗效确切,且安全性高,值得临床推广应用。Objective To investigate the clinical efficacy of azithromycin dry suspension combined with Saccharomyces boulardii in the treatment of infectious diarrhea in children.Methods A total of 78 children with infectious diarrhea admitted to our hospital from December 2018 to December 2020 were selected as the research subjects,they were divided into the observation group and the control group according to random number table method,with 39 children in each group.Both groups were given conventional treatment,the control group was treated with yeast burra,the observation group was treated with azithromycin dry suspension and yeast burra powder and montmorillonite powder treatment,the clinical efficacy,mean stool number at different time points,duration of diarrhea,recovery time,serum inflammatory indexes(interleukin-8[IL-8],interleukin-10[IL-10]and C-reactive protein[CRP])before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 94.87%,which was higher than 76.92%in the control group,the difference was statistically significant(P<0.05).There were statistically significant differences in between the two groups of group,time point and interaction.Comparison on within the group:the average stool time of each time point after treatment was less than that of the previous time point of the two groups,and the differences were statistically significant(P<0.05).Comparison between groups:before treatment,there was no significant difference in average stool times between the two groups;after 1,3 and 7 d of treatment,the average stool time in the observation group was less than that in the control group,and the differences were statistically significant(P<0.05).The duration and recovery time of diarrhea in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in IL-8,IL-10 and CRP levels between the two g

关 键 词：阿奇霉素混悬剂 布拉氏酵母菌 感染性腹泻 

分 类 号：R725.7[医药卫生—儿科]