不同时间点血浆促肾上腺皮质激素和皮质醇节律变化与原发性高血压的关系  

The relationship between the rhythm changes of plasma adrenocorticotropic hormone and cortisol and essential hypertension at different time points

作　　者：郭雅娜[1] 高雅琼 张莹[3] GUO Ya'na;GAO Yaqiong;ZHANG Ying(Department of Nuclear Medicine,the Second Affiliated Hospital of Baotou Medical College,Baotou,Inner Mongolia,014030,China;Department of Laboratory,the Third Hospital of Baotou City,Baotou,Inner Mongolia,014040,China;Department of Laboratory,Baotou City Cancer Hospital,Baotou,Inner Mongolia,014030,China)

机构地区：[1]包头医学院第二附属医院核医学科,内蒙古包头014031 [2]包头市第三医院检验科,内蒙古包头014040 [3]包头市肿瘤医院检验科,内蒙古包头014030

出　　处：《当代医学》2023年第13期181-184,共4页Contemporary Medicine

摘　　要：目的探讨不同时间点促肾上腺皮质激素(ACTH)与皮质醇(Cor)节律变化情况与原发性高血压(EH)的关系。方法选取2019年6月至2021年5月本院收治的100例EH患者作为研究组;另选取同期于本院体检100名健康体检者作为对照组。两组均接受ACTH、Cor检测,比较两组不同时间点ACTH、Cor水平,比较研究组单纯EH患者与EH合并心脑血管疾患者不同时间点ACTH、Cor水平。结果下午4:00~8:00,两组ACTH、Cor水平均低于上午6:00~10:00,差异有统计学意义(P<0.05);上午6:00~10:00、下午4:00~8:00,研究组ACTH水平均低于对照组,Cor水平均高于对照组,差异有统计学意义(P<0.05)。下午4:00~8:00,单纯EH患者与EH合并心脑血管疾病患者ACTH、Cor水平均低于上午6:00~10:00,差异有统计学意义(P<0.05);上午6:00~10:00、下午4:00~8:00,EH合并心脑血管疾病患者ACTH水平均低于单纯EH患者,Cor水平均高于单纯EH患者,差异有统计学意义(P<0.05)。结论不同时间点血浆ACTH、Cor节律变化与EH相关,有助于临床医生工作中进行参考。Objective To investigate the relationship between the rhythm changes of adrenocorticotropic hormone(ACTH)and cortisol(Cor)and essential hypertension(EH)at different time points.Methods 100 EH patients admitted to our hospital from June 2019 to May 2021 were selected as the study group;another 100 healthy subjects who underwent physical examination in our hospital during the same period were selected as the control group.ACTH and Cor were detected in two groups,and the levels of ACTH and Cor were compared at different time points,the levels of ACTH and Cor of patients with EH alone and those EH with cardiovascular and cerebrovascular diseases were compared at different time points in the study group.Results The levels of ACTH and Cor in the two groups from 4:00 to 8:00 PM were lower than those from 6:00 to 10:00 am,and the differences were statistically significant(P<0.05).The levels of ACTH in the study group were lower than those in the control group from 6:00 to 10:00 in the morning and 4:00 to 8:00 in the afternoon,and the levels of Cor were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of ACTH and Cor in patients with simple EH and EH complicated with cardiovascular and cerebrovascular diseases from 4:00 to 8:00 PM were lower than those from 6:00 to 10:00 am,and the difference was statistically significant(P<0.05).The levels of ACTH in EH with cardiovascular and cerebrovascular diseases patients were lower than those in simple the EH patients from 6:00 to 10:00 in the morning and 4:00 to 8:00 in the afternoon,and the levels of Cor were higher than those in simple the EH patients,and the differences were statistically significant(P<0.05).Conclusion The rhythm changes of plasma ACTH and Cor rhythm at different time points are related to EH,which is helpful for clinicians to refer to in their work.

关 键 词：原发性高血压 促肾上腺皮质激素 皮质醇 节律变化 不同时间点 

分 类 号：R544.1[医药卫生—心血管疾病]