纳洛酮静脉注射联合床旁血液灌流救治急性重症安眠药中毒的效果  

The effect of naloxone intravenous injection combined with bedside blood perfusion in the treatment of acute severe hypnotic poisoning

作　　者：焦林瑛 李公云 赵玉荣 JIAO Linying;LI Gongyun;ZHAO Yurong(Department of Emergency Internal Medicine,Linyi Mental Health Center,Linyi,Shandong,276005,China;Department of Cardiology,Linyi People's Hospital,Linyi,Shandong,276005,China;Department of Internal Medicine,Linyi Mental Health Center,Linyi,Shandong,276005,China)

机构地区：[1]临沂市精神卫生中心急诊内科,山东临沂276005 [2]临沂市人民医院心内科,山东临沂276005 [3]临沂市精神卫生中心内科,山东临沂276005

出　　处：《当代医学》2023年第17期73-76,共4页Contemporary Medicine

摘　　要：目的探讨纳洛酮静脉注射联合床旁血液灌流救治急性重症安眠药中毒的效果。方法选取2018年1月至2020年12月本院急诊科收治的82例急性重症安眠药中毒患者作为研究对象,依据入院时间不同分为实验组(2018年1月至2019年6月)与对照组(2019年7月至2020年12月),各41例。实验组给予急诊常规+纳洛酮静脉注射+床旁血液灌流治疗,对照组给予急诊常规+纳洛酮静脉注射治疗,比较两组救治成功率、治疗前后生理指标[收缩压(SBP)、舒张压(DBP)、心率(HR)、血氧饱和度(SpO_(2))、动脉血二氧化碳分压(PaCO_(2))]、基本急诊救治评价指标。结果实验组救治成功率高于对照组,差异有统计学意义(P<0.05)。急救前,两组SBP、DBP、HR、SpO_(2)、PaCO_(2)比较差异无统计学意义;急救后,两组SBP、DBP、HR、SpO_(2)均高于急救前,PaCO_(2)均低于急救前,且实验组SBP、DBP、HR、SpO_(2)均高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。实验组救治成功患者意识恢复时间、自主呼吸恢复时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。结论纳洛酮静脉注射联合床旁血液灌流救治急性重症安眠药患者效果确切,可促进患者早期意识与生命体征恢复正常,提高救治成功率,值得临床推广应用。Objective To investigate the effect of naloxone intravenous injection combined with bedside blood perfusion in the treatment of acute severe hypnotic poisoning.Methods 82 patients with acute severe hypnotic poisoning admitted to the emergency department of our hospital from January 2018 to December 2020 were selected as the research subjects,they were divided into the experimental group(January 2018 to June 2019)and control group(July 2019 to December 2020)according to the different admission time,with 41 cases in each group.The experimental group was treated with emergency routine+naloxone intravenous injection+bedside blood perfusion,and the control group was treated with emergency routine+naloxone intravenous injection,the success rate of treatment,physiological indexes(systolic blood pressure[SBP],diastolic blood pressure[DBP],heart rate[HR],blood oxygen saturation[SpO_(2)],partial pressure of blood carbon dioxide[PaCO_(2)])before and after treatment,and basic emergency treatment evaluation indexes were compared between the two groups.Results The success rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before emergency treatment,there was no significant difference in SBP,DBP,HR,SpO_(2)and PaCO_(2)between the two groups;after emergency treatment,the SBP,DBP,HR and SpO_(2)of the two groups were higher than those before emergency treatment,PaCO_(2)was lower than that before emergency treatment,and SBP,DBP,HR and SpO_(2)in the experimental group were higher than those in the control group,PaCO_(2)was lower than that in the control group,the differences were statistically significant(P<0.05).The consciousness recovery time,spontaneous breathing recovery time and hospitalization time in the experimental group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Naloxone intravenous injection combined with bedside blood perfusion is effective in the treatment of

关 键 词：安眠药中毒 急性重症 急诊治疗 纳洛酮 血液灌流 

分 类 号：R595.4[医药卫生—内科学]