血清SETDB1、COX-2水平与围绝经期骨质疏松骨代谢指标的相关性研究  

Correlation between serum SETDB1,COX-2 levels and bone metabolism indexes in perimenopausal osteoporosis patients

作　　者：吴阳春[1] 张镇兴 叶莼 Wu Yangchun;Zhang Zhenxing;Ye Chun(Department of Gynecology,Haining Maternal and Child Health Hospital,Haining 314400,China;Department of Orthopedics,Haining People's Hospital,Haining 314400,China;Department of Gynecology,Women's Hospital,Zhejiang University School of Medicine,Haining 310000,China)

机构地区：[1]海宁市妇幼保健院妇科,海宁314400 [2]海宁市人民医院骨科,海宁314400 [3]浙江大学附属妇产科医院妇科,海宁310000

出　　处：《中华内分泌外科杂志》2023年第4期480-483,共4页Chinese Journal of Endocrine Surgery

基　　金：浙江省卫生健康科技计划项目(2022KY1276)。

摘　　要：目的探讨围绝经期骨质疏松患者的血清SET结构域分支型1(SET domain bifurcated 1,SETDB1)、环氧合酶-2(cyclooxygenase-2,COX-2)水平与骨代谢指标的相关性。方法选取2018年8月至2021年8月海宁市妇幼保健院收治的71例围绝经期骨质疏松患者作为观察组,另选取50例健康人作为对照组。对两组的一般资料、骨密度和骨代谢指标进行测定。ELISA检测血清中SETDB1、COX-2的浓度。相关性分析明确血清SETDB1、COX-2水平与骨代谢指标的相关性。ROC曲线分析血清SETDB1、COX-2水平在诊断围绝经期骨质疏松中的价值。结果与对照组比较,观察组的骨密度、PINP、骨钙素水平均降低,但CTX水平增强(均P<0.001)。此外,与对照组(52.85±7.96)(4.88±1.00)比较,观察组的血清SETDB1浓度(40.25±7.08)降低,但COX-2浓度(7.28±2.09)增强(t=9.16,P<0.001;t=5.62,P<0.001)。SETDB1浓度与PINP和骨钙素呈正相关,与CTX浓度呈负相关(r=0.36、-0.40、0.34,P<0.001)。但COX-2浓度与PINP和骨钙素呈负相关,与CTX浓度呈正相关(r=-0.35、0.42、-0.37,P<0.001)。血清SETDB1和COX-2均能作为围绝经期骨质疏松诊断的有效指标(AUC=0.81,P<0.001;AUC=0.79,P<0.001)。结论血清SETDB1和COX-2水平能作为围绝经期骨质疏松患者的诊断指标,且二者和骨代谢指标有相关性。Objective To investigate the correlation between serum SET domain bifurcated 1(SETDB1),cyclooxygenase-2(COX-2)levels and bone metabolism indexes in perimenopausal osteoporosis patients.Methods 71 patients with perimenopausal osteoporosis admitted to Haining Maternal and Child Health Hospital from Aug.2018 to Aug.2021 were selected as the study group,and 50 healthy subjects were selected as the control group.The general data,bone mineral density and bone metabolism of the two groups were determined.The concen-trations of SETDB1 and COX-2 in serum were determined by ELISA.Correlation analysis was performed to deter-mine the correlation between serum SETDB1 and COX-2 levels and bone metabolism indexes.ROC curve was used to analyze the value of serum SETDB1 and COX-2 levels in the diagnosis of perimenopausal osteoporosis.Results Compared with the control group,bone mineral density,PINP and osteocalcin levels were decreased in the study group,but CTX levels were increased(all P<0.05).In addition,compared with the control group(52.85±7.96)(4.88±1.00),the concentration of SETDB1 in the study group was decreased(40.25±7.08),but the concentration of COX-2 was increased(7.28±2.09)(t=9.16,P<0.001;t=5.62,P<0.001).SETDB1 concentration was positively correlated with PINP and osteocalcin,and negatively correlated with CTX concentration(r=0.36,-0.40,0.34,P<0.001).However,COX-2 concentration was negatively correlated with PINP and osteocalcin,and positively corre-lated with CTX concentration(r=-0.35,0.42,-0.37,P<0.001).Serum SETDB1 and COX-2 were both effective indi-cators for the diagnosis of perimenopausal osteoporosis(AUC=0.81,P<0.01;AUC=0.79,P<0.001).Conclusion Serum SETDBl and COX-2 levels can be used as diagnostic indexes for perimenopausal osteoporosis patients,and they are correlated with bone metabolism indexes.

关 键 词：围经期 骨质疏松 骨代谢 

分 类 号：R580[医药卫生—内分泌]