加强补充钙和维生素D治疗抗骨质疏松药相关甲状旁腺功能亢进一例报道  

One case report of a patient with anti-osteoporosis drug related hyperparathyroidism cured after strength-ening calcium and vitamin D supplementation

作　　者：母力元 孔令泉[1] 吴凯南[1] Mu Liyuan;Kong Lingquan;WuKainan(Department of Breast and Thyroid Surgery,the First Afiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院乳腺甲状腺外科,重庆400016

出　　处：《中华内分泌外科杂志》2023年第4期511-512,共2页Chinese Journal of Endocrine Surgery

摘　　要：抗骨质疏松药是治疗骨质疏松症的重要手段,但部分患者使用后出现全身骨关节肌肉疼痛未缓解或加剧等不良反应,可能与抗骨质疏松药相关甲状旁腺功能增强或亢进相关。本文报道一例78岁女性骨质疏松患者,在常规补充维生素D和钙剂基础上,使用抗骨质疏松药后出现血钙降低及负钙平衡,致甲状旁腺功能亢进,双膝关节明显疼痛,无法行走。经充分补充维生素D和钙剂后,患者双膝关节疼痛明显缓解,可独立行走,骨代谢指标恢复正常,一年后随访病情稳定未复发。Anti-osteoporosis drug is important to treat osteoporosis.However,systemic musculoskeletal and joints pain and other adverse events in some patients are unrelieved or even aggravated after using anti-osteoporosis drugs,which may be associated with anti-osteoporosis drug related parathyroid hyperfunction or hyperparathyroidism.We report a case of 78 years old female with osteoporosis who,on the basis of conventional regular supplementation of Vitamin D and calcium supplements,presented with a decreased level of serum calcium and negative calcium balance after receiving anti-osteoporosis drugs,resulting in hyperparathyroidism,significant pain in bilateral knee joints and inability of walking independently.After sufficient supplementation of vitamin D and calcium,the pain was significantly relieved,bone metabolism indicators returned to normal,the patient was able to walk without assistance and had no recurrence after 1 year of follow-up.

关 键 词：骨质疏松症 抗骨质疏松药 甲状旁腺功能亢进 维生素D 钙剂 

分 类 号：R580[医药卫生—内分泌] R582.1[医药卫生—内科学]