基于液态金属影像增强和M序列编码激励的磁声电层析成像方法研究  

Research on magneto-acoustic-electrical tomography method based on liquid metal contrast agent and M sequence coded excitation

作　　者：王玉恒 林俊杰 买文姝 刘志朋[1] 殷涛[1] 张顺起[1] WANG Yuheng;LIN Junjie;MAI Wenshu;LIU Zhipeng;YIN Tao;ZHANG Shunqi(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300000,P.R.China)

机构地区：[1]中国医学科学院北京协和医学院生物医学工程研究所,天津300000

出　　处：《生物医学工程学杂志》2023年第4期718-724,735,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金(61871406,81927806);天津市自然科学基金多元投入基金项目面上项目(21JCYBJC00870);中国医学科学院医学与健康科技创新工程(2021-I2M-1-058)。

摘　　要：磁声电层析成像(MAET)具有超声成像高分辨率和电阻抗成像高对比度的优点,在肿瘤早期诊断和生物电流监测方面具有重要研究价值。为了提高MAET的信噪比,对结合高电导率液态金属和最长线性移位寄存器序列(M序列)编码激励方法进行了研究。结果显示,在旋转扫描下,液态金属可显著提高组织间磁声电信号信噪比,增强图像质量。在7、15、31、63位M序列编码激励下,磁声电信号的信噪比分别提升了5.6、11.1、21.7、45.7倍。提升相同信噪比时,31位M序列编码激励成像的总使用时间相比单脉冲激励缩短了75.6%。总之,结合液态金属和M序列编码激励的成像方法对提高MAET图像质量具有积极意义。Magneto-acoustic-electric tomography(MAET)boasts high resolution in ultrasound imaging and high contrast in electrical impedance imaging,making it of significant research value in the fields of early tumor diagnosis and bioelectrical monitoring.In this study,a method was proposed that combined high conductivity liquid metal and maximum length sequence(M sequence)coded excitation to improve the signal-to-noise ratio.It was shown that,under rotational scanning,the liquid metal significantly improved the signal-to-noise ratio of the inter-tissue magneto-acousticelectric signal and enhanced the quality of the reconstructed image.The signal-to-noise ratio of the signal was increased by 5.6,11.1,21.7,and 45.7 times under the excitation of 7-,15-,31-,and 63-bit M sequence code,respectively.The total usage time of 31-bit M sequence coded excitation imaging was shortened by 75.6%compared with single-pulse excitation when the same signal-to-noise ratio was improved.In conclusion,the imaging method combining liquid metal and M-sequence coding excitation has positive significance for improving MAET image quality.

关 键 词：磁声电层析成像 液态金属 最长线性移位寄存器序列 编码激励 

分 类 号：R318[医药卫生—生物医学工程] TP391.41[医药卫生—基础医学]