海藻酸钠微球的制备及应用研究进展  

Progress in preparation and application of sodium alginate microspheres

作　　者：刘轩妤 王玉辉 梁紫微 连小洁 黄棣[1,2] 胡银春(综述) 魏延(审校)[1,2] LIU Xuanyu;WANG Yuhui;LIANG Ziwei;LIAN Xiaojie;HUANG Di;HU Yinchun;WEI Yan(Department of Biomedical Engineering,Research Center for Nano-biomaterials&Regenerative Medicine,College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China;Shanxi Key Laboratory of Material Strength&Structural Impact,Institute of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China)

机构地区：[1]太原理工大学生物医学工程学院生物医学工程系,纳米生物材料与再生医学研究中心,太原030024 [2]太原理工大学生物医学工程研究所,材料强度与结构冲击山西省重点实验室,太原030024

出　　处：《生物医学工程学杂志》2023年第4期792-798,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(12272253,82103147,12202302);山西省应用基础研究计划项目(202203021221047,20210302124007,20210302124405);山西省回国留学人员科研资助项目(HGKY2019037)。

摘　　要：海藻酸钠(SA)是从褐藻类海带中提取的一种天然高分子材料,具备出色的生物相容性、无毒性、生物降解性以及丰富的储存量。海藻酸钠凝胶形成的条件温和,可有效避免活性物质的失活。经过多种制备方法,海藻酸钠微球被广泛用于生物材料和组织工程等领域。本文综述了制备海藻酸钠微球的常见方法,包括挤出法、乳化法、静电喷射法、喷雾干燥法和同轴气流法,并探讨了它在骨修复、止血以及药物递送等生物医学领域的应用。Sodium alginate(SA)is a kind of natural polymer material extracted from kelp,which has excellent biocompatibility,non-toxicity,biodegradability and abundant storage capacity.The formation condition of sodium alginate gel is mild,effectively avoiding the inactivation of active substances.After a variety of preparation methods,sodium alginate microspheres are widely used in the fields of biomaterials and tissue engineering.This paper reviewed the common methods of preparing alginate microspheres,including extrusion,emulsification,electrostatic spraying,spray drying and coaxial airflow,and discussed their applications in biomedical fields such as bone repair,hemostasis and drug delivery.

关 键 词：海藻酸钠微球 骨修复 止血 药物递送 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程] TQ317[医药卫生—基础医学]